NCT01821066 - A Study To Determine If Coadministration Of Tamoxifen Alters The Extent Or Rate Of Palbociclib (PD-0332991) Absorption Or Elimination In Healthy Male Volunteers | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

April 30, 2013

Primary Completion Date

August 31, 2013

Study Completion Date

August 31, 2013

Conditions

Healthy

Interventions

DRUG

PD-0332991 alone

PD-0332991 is administered alone as a single oral 125 mg dose on Day 1 of Period 1.

DRUG

Tamoxifen 60 mg

On Days 1-4 of Period 2, tamoxifen is administered daily as 60 mg oral doses (using three 20mg tablets).

DRUG

Tamoxifen 20 mg

On Days 5-27 of Period 2, tamoxifen is administered daily as 20 mg oral doses.

DRUG

PD-0332991 combination

PD-0332991 is administered in combination with tamoxifen on Day 22 of Period 2 as a single 125 mg oral dose.

Trial Locations (1)

Pfizer Investigational Site, New Haven