Surgical Indirect Revascularization For Symptomatic Intracranial Arterial Stenosis

NACompletedINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

March 31, 2013

Primary Completion Date

June 30, 2018

Study Completion Date

June 30, 2018

Conditions
Intracranial Arterial StenosisIntracranial AtherosclerosisIschemic StrokeCerebral Angiogenesis
Interventions
PROCEDURE

Encephaloduroarteriosynangiosis (EDAS)

The operation is a form of indirect revascularization or EC-IC bypass, performed under general endotracheal anesthesia, with intraoperative electroencephalographic monitoring. The surgery consists in the dissection and relocation of the superficial temporal artery (STA) and middle meningeal artery (MMA) branches, which are separated from their surrounding tissues under microscopic visualization and re-routed through a craniotomy to be placed intracranially in close proximity to the branches of the middle cerebral artery (MCA). The MCA branches are dissected in the arachnoid space and the STA and MMA are kept in position with microsutures to the arachnoid or MMA dural cuffs, maintaining close contact between the EC and MCA branches.

Trial Locations (1)

90048

Cedars Sinai Medical Center, Los Angeles

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

lead

Cedars-Sinai Medical Center

OTHER

NCT01819597 - Surgical Indirect Revascularization For Symptomatic Intracranial Arterial Stenosis | Biotech Hunter | Biotech Hunter