316
Participants
Start Date
July 16, 2013
Primary Completion Date
January 4, 2023
Study Completion Date
January 4, 2023
Vitamin D
Patients will receive 100.000 UI of cholecalciferol every 14 days for a maximum of 24 months or until conversion to full multiple sclerosis has occurred.
Placebo
Patients will receive a placebo treatment mimicking 100.000 UI of cholecalciferol every 14 days for a maximum of 24 months or until conversion to full multiple sclerosis has occurred.
Imaging
All patients are scheduled for MRI scans at baseline, 3 months, 12 months, 24 months, as well as upon conversion to full MS.
Lumbar puncture
A baseline collection of cerebral spinal fluid may be required for certain patients (doctor's decision.)
Blood sampling
Blood sampling is required of all patients at baseline, 3 months, 6 months, 12 months, 18 months and 24 months, as well as upon conversion to MS.
Urine samples
Urine samples are required of all patients at baseline, 3 months, 6 months, 12 months, 18 months, 24 months, and upon conversion to MS.
CHU de Caen - Hôpital Côte de Nacre, Caen
CHU de Dijon, Dijon
CH de Cornouaille - Site Quimper - Hôpital Laennec, Quimper
CHU de Nîmes - Hôpital Universitaire Carémeau, Nîmes
CHRU de Toulouse - Hôpital Purpan, Toulouse
Clinique des Cèdres - Capio, Cornebarrieu
CHU de Montpellier - Hôpital Gui de Chauliac, Montpellier
CHU de Rennes - Hôpital PontChaillou, Rennes
CHRU de Tours - Hôpital Bretonneau, Tours
CHU de Grenoble - Hôpital A Michallon, Grenoble
CHU de Nantes - Hôtel-Dieu, Nantes
CH de Saumur, Saumur
CHU de Reims - Hôpital Maison Blanche, Reims
CHU de Nancy - Hôpital Central, Nancy
CHRU de Lille - Hôpital Roger Salengro, Lille
Groupe Hospitalier de l'Institut Catholique de Lille, Lomme
CHU de Clermont Ferrand - Hôpital Gabriel-Montpied, Clermont-Ferrand
CH de Pau, Pau
CH de Perpignan - Hôpital Saint Jean, Perpignan
CHRU de Strasbourg - Hôpital Civil, Strasbourg
CHU de Lyon - Hôpital Pierre Wertheimer, Bron
MAILLART Elisabeth - La Pitié Salpétrière, Paris
Fondation Ophtalmologique Adolphe Rothschild, Paris
APHP - Hôpital Saint-Antoine, Paris
CHU de Rouen - Hôpital Charles Nicolle, Rouen
CH de Versailles - Hôpital Mignot, Versailles
CH de Poissy - Saint-Germain-en-Laye, Saint-Germain-en-Laye
CHU d'Amiens - Hôpital Nord, Amiens
CHU de Limoges - Hôpital Dupuytren, Limoges
CH Sud Francilien, Corbeil-Essonnes
CHU de Martinique - Hôpital Pierre Zobda-Quitman, Fort-de-France
CHU de Nice - Hôpital Pasteur, Nice
CH de Vichy - Jacques Larin, Vichy
Centre Hospitalier Universitaire de Nīmes
OTHER