Neoadjuvant Chemoradiotherapy vs. Chemotherapy Followed by Radical Gastrectomy and Adjuvant Chemotherapy for Advanced Gastric Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

620

Participants

Timeline

Start Date

June 30, 2013

Primary Completion Date

June 30, 2025

Study Completion Date

June 30, 2025

Conditions
Gastric Cancer
Interventions
RADIATION

Neoadjuvant Chemoradiotherapy

Radiotherapy (45Gy/25f) + 3 cycles of XELOX Chemotherapy \[Oxaliplatin 130 mg/m² IV on Day 1 + Capecitabine 1000 mg/m² orally BID on Days 1-14 of a 21-day cycle (non-concurrent); Oxaliplatin 100 mg/m² IV on Day 1 + Capecitabine 825 mg/m² orally BID on Days 1-14 of a 21-day cycle (concurrent chemoradiotherapy)\]

DRUG

Neoadjuvant Chemotherapy

3 cycles of XELOX Chemotherapy (Oxaliplatin 130 mg/m² IV on Day 1 + Capecitabine 1000 mg/m² orally BID on Days 1-14 of a 21-day cycle)

PROCEDURE

R0 D2 Gastrectomy

DRUG

Adjuvant Chemotherapy

3 cycles of XELOX Chemotherapy (Oxaliplatin 130 mg/m² IV on Day 1 + Capecitabine 1000 mg/m² orally BID on Days 1-14 of a 21-day cycle)

Trial Locations (1)

510060

Sun Yat-sen University Cancer Center, Guangzhou

All Listed Sponsors
collaborator

The First Affiliated Hospital of Anhui Medical University

OTHER

collaborator

Liaoning Cancer Hospital & Institute

OTHER

collaborator

Guangdong Provincial Hospital of Traditional Chinese Medicine

OTHER

collaborator

Tianjin Medical University Cancer Institute and Hospital

OTHER

collaborator

Zhejiang Cancer Hospital

OTHER

collaborator

First Hospital of China Medical University

OTHER

collaborator

The Affiliated Tumor Hospital of Guangxi Medical University

UNKNOWN

collaborator

Hangzhou First People's Hospital, School of Medicine, Zhejiang Universiry

UNKNOWN

collaborator

The Affiliated Hospital of Qingdao University

OTHER

collaborator

Guangdong Provincial People's Hospital

OTHER

collaborator

Sichuan Cancer Hospital and Research Institute

OTHER

collaborator

National Clinical Research Center for Cancer/Cancer Hospital

UNKNOWN

lead

Sun Yat-sen University

OTHER

NCT01815853 - Neoadjuvant Chemoradiotherapy vs. Chemotherapy Followed by Radical Gastrectomy and Adjuvant Chemotherapy for Advanced Gastric Cancer | Biotech Hunter | Biotech Hunter