Efficacy Study on Dimethyl Fumarate to Treat Moderate to Severe Plaque Psoriasis

500 mg FP187 daily, two tablets of 125 mg twice daily, from 125 mg daily up-titrated to full dose over a 4-week phase, total treatment phase of 20 weeks

720 mg Fumaderm® daily, two tablets of 120 mg three times daily, from 30 mg daily up-titrated to full dose over a 9-week phase, total treatment phase of 20 weeks

FP187 matching placebo tablets in the same regimen as for FP187 arm

Fumaderm® matching placebo tablets in the same regimen as for Fumaderm® arm