23
Participants
Start Date
June 30, 2011
Primary Completion Date
March 24, 2017
Study Completion Date
March 24, 2017
Metformin
Six week intervention: Study drug/placebo will be given in a forced uptitration with 500 mg once daily for one week, 500 mg twice daily for one week, 500/1000 for one week, and then 1000mg twice daily for the remainder of the 6 week intervention. If uptitration is not tolerated, max dose will be max tolerated dose of at least 500 mg twice daily.
Placebo
Six-week intervention: Study drug/placebo will be given in a forced uptitration with 500 mg once daily for one week, 500 mg twice daily for one week, and then the higher dose (850 mg) for the remainder of the 6 week intervention.
University of Colorado Denver, Aurora
US Department of Veterans Affairs
FED
University of Colorado, Denver
OTHER