Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

104

Participants

Timeline

Start Date

September 30, 2013

Primary Completion Date

October 31, 2018

Study Completion Date

October 31, 2018

Conditions
Acute Alcoholic Hepatitis
Interventions
DRUG

Anakinra

Anakinra, interleukin-1 receptor antagonist; 100 mg/0.67 mL solution for subcutaneous injection.

DRUG

Pentoxifylline

Pentoxifylline, generic

DRUG

Zinc Sulfate

Zinc Sulfate, nutritional supplement

DRUG

Methylprednisolone

Methylprednisolone, corticosteroid

Trial Locations (4)

40202

University of Louisville, Louisville

44195

Cleveland Clinic, Cleveland

01655

University of Massachusetts Medical School, Worcester

75390-9030

University of Texas Southwestern Medical Center, Dallas

All Listed Sponsors
collaborator

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NIH

collaborator

The Cleveland Clinic

OTHER

collaborator

University of Massachusetts, Worcester

OTHER

collaborator

University of Louisville

OTHER

lead

Mack Mitchell

OTHER

NCT01809132 - Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis | Biotech Hunter | Biotech Hunter