Study to Evaluate the Safety and Tolerability of Andecaliximab as Monotherapy and in Combination With Chemotherapy in Participants With Advanced Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

236

Participants

Timeline

Start Date

March 29, 2013

Primary Completion Date

April 23, 2019

Study Completion Date

April 23, 2019

Conditions
Pancreatic CancerNon-small Cell Lung CancerEsophagogastric CancerColorectal CancerBreast Cancer
Interventions
DRUG

Andecaliximab

Administered intravenous infusion

DRUG

Gemcitabine

Administered intravenously on Days 1, 8, and 15 of each 28-day treatment cycle

DRUG

Nab-paclitaxel

Administered intravenously on Days 1, 8, and 15 of each 28-day treatment cycle

DRUG

Carboplatin

Administered intravenously on Day 1 of each 21-day treatment cycle

DRUG

Pemetrexed

Administered intravenously on Day 1 of each 21-day treatment cycle

DRUG

Leucovorin

Administered intravenously on Days 1 and 15 of each 28-day treatment cycle

DRUG

Oxaliplatin

Administered intravenously on Days 1 and 15 of each 28-day treatment cycle

DRUG

5-FU

Administered intravenously on Days 1 and 15 of each 28-day treatment cycle

DRUG

Bevacizumab

Administered intravenously on Days 1 and 15 of each 28-day treatment cycle

DRUG

Irinotecan

Administered intravenously on Days 1 and 15 of each 28-day treatment cycle

DRUG

Paclitaxel

Administered intravenously on Days 1, 8 and 15 of each 28-day treatment cycle (Breast cancer) or on Day 1 of each 21-day treatment cycle (NSCLC)

Trial Locations (18)

10021

Cornell University, New York

29605

Greenville Health System, Institute for Translational Oncology Research, Greenville

34232

Florida Cancer Specialists, Sarasota

35243

Alabama Oncology, Birmingham

37203

Sarah Cannon Research Institute, Nashville

37232

Vanderbilt, Nashville

46526

Indiana University Health Goshen Center for Cancer Care, Goshen

46845

Parkview Research Center, Fort Wayne

63110

Washington University School of Medicine, St Louis

75390

UT Southwestern, Dallas

84112

University of Utah, Salt Lake City

85258

Pinnacle Oncology Hematology, Scottsdale

90033

University of Southern California (USC), Los Angeles

90404

UCLA Medical Center, Santa Monica

92024

San Diego Pacific Oncology and Hematology Associates, Inc., Encinitas

93309

Comprehensive Blood and Cancer Center, Bakersfield

94115

California Pacific Medical Center, San Francisco

98405

Northwest Medical Specialties, Tacoma

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY

NCT01803282 - Study to Evaluate the Safety and Tolerability of Andecaliximab as Monotherapy and in Combination With Chemotherapy in Participants With Advanced Solid Tumors | Biotech Hunter | Biotech Hunter