Study of Fulvestrant +/- Everolimus in Post-Menopausal, Hormone-Receptor + Metastatic Breast Ca Resistant to AI

PHASE2CompletedINTERVENTIONAL
Enrollment

131

Participants

Timeline

Start Date

May 31, 2013

Primary Completion Date

March 22, 2017

Study Completion Date

September 12, 2017

Conditions
Metastatic Breast Cancer
Interventions
DRUG

Fulvestrant

"Fulvestrant 500 mg Day 1 \& 15 of Cycle 1, then 500 mg Day 1 of all subsequent cycles (every 28 days for 12 cycles).~If no evidence of disease progression after 12 cycles, unblind and continue same dose and schedule until progression or unacceptable toxicity."

DRUG

Everolimus

"Everolimus 10 mg (2 tablets) daily x 12 cycles.~If no evidence of disease progression after 12 cycles, unblind and continue same dose and schedule until progression or unacceptable toxicity."

DRUG

Placebo

Placebo for Everolimus (2 tablets) daily x 12 cycles. Placebo manufactured to mimic everolimus tablet.

Trial Locations (25)

10011

Beth Israel, New York

10466

Montefiore Medical Center, The Bronx

15213

University of Pittsburgh- Magee Women's Hospital, Pittsburgh

17033

Penn State University, Hershey

18512

Hematology & Oncology Associates of Northeastern PA, PC, Dunmore

19096

Main Line Heath System, Wynnewood

19107

Thomas Jefferson University, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

19611

Reading Hospital- McGlinn Family Regional Cancer Center, West Reading

21287

Johns Hopkins University, Baltimore

25304

Charleston Area Medical Center (CAMC), Charleston

43210

Ohio State University Medical Center, Columbus

43617

Toledo COP, Toledo

48158

St. Joseph Mercy Hospital (MI Cancer Consortium), Ann Arbor

53188

ProHealth Care Inc. (Waukesha), Waukesha

53226

Aurora Cancer Care, Wauwatosa

54301

St. Vincent Hospital, Green Bay

54601

Gundersen Health System, La Crosse

55416

Metro MN, Saint Louis Park

61104

SwedishAmerican Regional Cancer Center, Rockford

68106

Missouri Valley Cancer Consortium, Omaha

75390

University of Texas Southwestern, Dallas

94305

Stanford University, Stanford

94904

Marin Cancer Care, Greenbrae

50010-3014

McFarland Clinic, PC, Ames

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis

INDUSTRY

lead

PrECOG, LLC.

OTHER