Low Dose Aspirin Inhibition of COX-2 Derived PGE2 in Male Smokers

EARLY_PHASE1CompletedINTERVENTIONAL
Enrollment

6

Participants

Timeline

Start Date

February 28, 2013

Primary Completion Date

February 29, 2016

Study Completion Date

February 29, 2016

Conditions
Tobacco Use DisorderSmoking
Interventions
DRUG

Aspirin 325 mg daily

In this single-arm trial, participants will take celecoxib 200 mg BID for 5 doses, followed by aspirin 325 mg daily for 10 days, followed by combination of celecoxib 200 mg BID for 5 doses and aspirin 325 mg daily for 3 days.

DRUG

Celecoxib 200 mg BID

In this single-arm trial, participants will take celecoxib 200 mg BID for 5 doses, followed by aspirin 325 mg daily for 10 days, followed by combination of celecoxib 200 mg BID for 5 doses and aspirin 325 mg daily for 3 days.

Trial Locations (1)

37212

Vanderbilt University, Nashville

All Listed Sponsors
lead

Vanderbilt University

OTHER

NCT01796951 - Low Dose Aspirin Inhibition of COX-2 Derived PGE2 in Male Smokers | Biotech Hunter | Biotech Hunter