A Pharmacokinetic Evaluation of Levonorgestrel Implant and Antiretroviral Therapy

PHASE2CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

March 4, 2014

Primary Completion Date

September 1, 2014

Study Completion Date

March 4, 2015

Conditions
HIVContraception
Interventions
DRUG

Levonorgestrel

Levonorgestrel 2-rod subdermal implant (75mg/rod) placed on study day 0 after baseline evaluations and remains in place until the subject requests removal or for the duration of drug activity (currently approved for 5 years).

DRUG

Nevirapine

Nevirapine 200mg twice daily as part of a complete antiretroviral therapy regimen. Subjects will be on this therapy prior to entry in this study.

DRUG

Efavirenz

Efavirenz 600mg once daily as part of a complete antiretroviral therapy regimen. Subjects will be on this therapy prior to entry in this study.

Trial Locations (1)

Unknown

Infectious Diseases Institute, Kampala

All Listed Sponsors
collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

collaborator

Makerere University

OTHER

collaborator

University of Liverpool

OTHER

lead

University of Nebraska

OTHER

NCT01789879 - A Pharmacokinetic Evaluation of Levonorgestrel Implant and Antiretroviral Therapy | Biotech Hunter | Biotech Hunter