Evaluating the Safety and Immune Response to Three HIV Vaccine Schedules in Healthy, HIV-Uninfected Adults

PHASE1CompletedINTERVENTIONAL
Enrollment

143

Participants

Timeline

Start Date

April 30, 2013

Primary Completion Date

September 30, 2014

Study Completion Date

October 24, 2018

Conditions
HIV Infections
Interventions
BIOLOGICAL

DNA-HIV-PT123 vaccine

DNA-HIV-PT123 4 mg/mL; administered as 1 mL IM in participant's deltoid

BIOLOGICAL

NYVAC-HIV-PT1 vaccine

NYVAC-HIV-PT1 at greater than or equal to 5x10\^6 plaque-forming units (PFU)/ml for a planned maximum dose of 1.2x10\^8 PFU/ml; administered as 1 mL IM in participant's deltoid

BIOLOGICAL

NYVAC-HIV-PT4 vaccine

NYVAC-HIV-PT4 at greater than or equal to 5x10\^6 PFU/ml for a planned maximum dose of 1.1x10\^7 PFU/ml; administered as 1 mL IM in participant's deltoid

BIOLOGICAL

Placebo for DNA-HIV-PT123 vaccine

Placebo for DNA-HIV-PT123 administered as 1 mL IM in participant's deltoid

BIOLOGICAL

Placebo for NYVAC-HIV-PT1 vaccine

Placebo for NYVAC-HIV-PT1 vaccine administered as 1 mL IM in participant's deltoid

BIOLOGICAL

Placebo for NYVAC-HIV-PT4 vaccine

Placebo for NYVAC-HIV-PT4 vaccine administered as 1 mL IM in the participant's deltoid

Trial Locations (8)

1011

Lausanne Vaccine and Immunotherapy Center CRS, Lausanne

19104

Penn Prevention Crs, Philadelphia

30030

The Hope Clinic of the Emory Vaccine Center CRS, Decatur

35294

Alabama CRS, Birmingham

60612

UIC Project WISH CRS, Chicago

94143

Bridge HIV CRS, San Francisco

02115-6110

Brigham and Women's Hospital Vaccine CRS (BWH VCRS), Boston

98109-1024

Seattle Vaccine and Prevention CRS, Seattle

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT01783977 - Evaluating the Safety and Immune Response to Three HIV Vaccine Schedules in Healthy, HIV-Uninfected Adults | Biotech Hunter | Biotech Hunter