NCT01782755 - Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT): A Feasibility Clinical Trial | Biotech Hunter

Enrollment

150

Participants

Timeline

Start Date

October 31, 2013

Primary Completion Date

August 31, 2014

Study Completion Date

January 31, 2015

Conditions

Ventilator Associated Pneumonia (VAP)Other InfectionsAntibiotic-Associated DiarrheaC-DifficileDuration of Mechanical VentilationLength of ICU StayLength of Hospital StayICU and Hospital Mortality

Interventions

DRUG

L. rhamnosus GG - Probiotic

Twice daily, patients will receive either 1x1010 colony forming units (CFU) of L. rhamnosus GG (Culturelle, Locin Industries Ltd) in 1 capsule or an identical placebo capsule

OTHER

Placebo - Microcrystalline Cellulose

Placebo capsule, twice daily (containing Microcrystalline Cellulose)

Trial Locations (14)

55905

Mayo Clinic, Rochester

63141

St. John's Mercy Medical Center, St Louis

V5Z 1M9

Vancouver General Hospital, Vancouver

V6Z1Y6

St. Paul's Hospital, Vancouver

V8R 1J8

Vancouver Island Health Authority, Victoria

L8L 2X2

Hamilton Health Science - Hamilton General Hospital, Hamilton

L8N 4A6

St Joseph's Healthcare Hamilton, Hamilton

L8V 1C3

Hamilton Health Science - Juravinski Hospital, Hamilton

K1H 8G7

Ottawa Hospital Research Institute - Civic Campus, Ottawa

K1H 8L6

Ottawa Research Institute - General Hospital, Ottawa

M5B 1W8

St Michael's Hospital, Toronto

M5G 1X5

Mount Sinai Hospital, Toronto

Unknown

University Health Network - Toronto Western Hospital, Toronto

G1J 1Z4

Hopital de l'Enfant Jesus, Québec

All Listed Sponsors

collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

collaborator

Technology Evaluation in the Elderly Network (TVN)

UNKNOWN

collaborator

Physician's Services Incorporated (PSI)

UNKNOWN

collaborator

Hamilton Academy of Health Science Research Organization (HAHSO)

UNKNOWN

lead

McMaster University

OTHER