A Study of BBI608 in Adult Patients With Advanced Colorectal Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

March 31, 2012

Primary Completion Date

June 30, 2018

Study Completion Date

April 30, 2020

Conditions
Colorectal Cancer
Interventions
DRUG

BBI608

BBI608 is administered at 500 mg po bid continuously.

DRUG

Panitumumab

Panitumumab will be administered IV on day 8 and 22 of each 28 day cycle at 6 mg/kg over 60 minutes.

DRUG

Capecitabine

Capecitabine will be administered orally at 1000 mg/m2 bid daily on days 8-21 every three weeks.

DRUG

Cetuximab

Cetuximab will be administered IV on day 5 at 400 mg/m2 intravenous infusion over 120 minutes as the initial dose, then weekly at 250mg/m2 over 60-minutes at subsequent cycles.

Trial Locations (13)

19104

Abramson Cancer Center of the University of Pennsylvania, Philadelphia

22031

USOR - Virginia Cancer Specialists, Fairfax

29605

Institute for Translational Oncology Research, Greenville Hospital System, Greenville

32224

Mayo Clinic, Jacksonville

43210

The Ohio State University Comprehensive Cancer Center, Columbus

55404

USOR - Minnesota Oncology Hematology, Minneapolis

55905

Mayo Clinic, Rochester

75246

USOR - Texas Oncology Dallas, Dallas

75702

USOR - Texas Oncology Tyler, Tyler

77380

US Oncology Research, The Woodlands

80218

USOR - Rocky Mountain Cancer Center, Denver

85259

Mayo Clinic, Scottsdale

97227

USOR - Northwest Cancer Specialists, Portland

All Listed Sponsors
lead

Sumitomo Pharma America, Inc.

INDUSTRY

NCT01776307 - A Study of BBI608 in Adult Patients With Advanced Colorectal Cancer | Biotech Hunter | Biotech Hunter