780
Participants
Start Date
June 10, 2013
Primary Completion Date
December 9, 2016
Study Completion Date
December 31, 2019
5-Fluorouracil
Participants will receive 5-fluorouracil 800 milligrams per meter square (mg/m\^2)/24 hour IV infusion for 120 hours (Days 1-5) q3w for 6 cycles.
Capecitabine
Participants will receive capecitabine 1000 mg/m\^2 orally twice daily, evening of Day 1 to morning of Day 15 (28 doses) q3w for 6 cycles.
Cisplatin
Participants will receive cisplatin 80 mg/m\^2 IV q3w for 6 cycles.
Pertuzumab
Participants will receive pertuzumab 840 mg IV q3w until disease progression, occurrence of unacceptable toxicity, or withdrawal from the study for another reason.
Placebo
Participants will receive placebo (matched to pertuzumab) IV q3w until disease progression, occurrence of unacceptable toxicity, or withdrawal from the study for another reason.
Trastuzumab
Participants will receive 8 mg/kg IV initial dose on Day 1, followed by 6 mg/kg IV q3w until disease progression, occurrence of unacceptable toxicity, or withdrawal from the study for another reason.
National Taiwan Uni Hospital; Dept of Oncology, Taipei
Taipei Veterans General Hospital, Taipei
Chang Gung Medical Foundation - Linkou; Division of Hematology- Oncology, Taoyuan District
Taichung Veterans General Hospital; Dept of Surgery, Taichung
University Clinic for Radiotherapy and Oncology, Skopje
CHUV; Departement d'Oncologie, Lausanne
Semmelweis Egyetem Onkologiai Központ, Budapest
Orszagos Onkologiai Intezet; B Belgyogyaszati Osztaly, Budapest
Cliniques Universitaires St-Luc, Brussels
MHAT Serdika, Sofia
Austin Health; Cancer Clinical Trial Centre, Heidelberg
Monash Medical Centre; Oncology, Clayton
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz;Sugarterapias Klinikai Onkologiai Intez, Miskolc
Complex Oncological Center - Plovdiv, EOOD, Plovdiv
Royal Brisbane Womens Hosp; Division of Oncology, Herston
Debreceni Egyetem, Klinikai Kozpont, Onkologiai Klinika, Debrecen
Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt., Salzburg
Luzerner Kantonsspital; Medizinische Onkologie, Lucerne
Sir Charles Gairdner Hospital; Medical Oncology, Perth
Krankenhaus St. Vinzenz Der Barmherzigen Schwestern Zams; Abt. Für Innere Medizin, Zams
Szegedi Tudomanyegyetem, AOK, Szent-Gyorgyi Albert Klinikai Kozpont, Onkoterapias Klinika, Szeged
Clinical Hospital; Oncology Department, Bitola
SHATOD Dr. Marko Antonov Markov-Varna, EOOD; Department of Medicinall Onchotherapy and Palliative, Varna
Clinical Hospital Centre Zagreb, Zagreb
Clinical Hospital Sisters of Mercy, Zagreb
Weill Medical College of Cornell University; Division of Hematology & Medical Oncology, New York
Charité-Universitätsm. Berlin; Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunolo., Berlin
Rajavithi Hospital; Division of Medical Oncology, Bangkok
Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc, Bangkok
Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology, Bangkok
Queens Medical Associates, Fresh Meadows
New York Oncology Hematology, P.C., Albany
Inst. Nacional de Cancerologia; Investigacion Clinica, Mexico City
Hospital Universitario Reina Sofia; Servicio de Oncologia, Córdoba
Hospital Universiti Sains Malaysia [Neurology], Kubang Kerian
Irccs Ospedale San Raffaele, Milan
Irccs Istituto Europeo Di Oncologia (IEO); Oncologia Medica, Milan
Universitätsklinikum Hamburg-Eppendorf; Hubertus Wald Tumorzentrum, Hamburg
Turku Uni Central Hospital; Oncology Clinics, Turku
Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department, Edirne
Asst Papa Giovanni XXIII; Oncologia Medica, Bergamo
Ataturk University Medical Faculty Yakutiye Research Hospital Medical Oncology Department, Erzurum
Hospital Ramon y Cajal; Servicio de Oncologia, Madrid
Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid
Medical University of South Carolina; Hollings Cancer Center, Charleston
Azienda Ospedaliero-Universitaria Dipartimento Interaziendale Di Oncologia, Udine
Florida Cancer Specialists - SCRI; Pharmacy, Fort Myers
Istanbul Uni Cerrahpasa Medical Faculty Hospital; Medical Oncology, Istanbul
Philipps-Universität Marburg; Klinik für Innere Med.; Schwerpunkt Hämatologie/Onkologie/Immunologie, Marburg
Tennessee Oncology PLLC - Nashville (20th Ave), Nashville
Khonkaen Hospital, Khonkaen
Azienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unità Operativa Oncologia Medica, Bologna
Kyungpook National University Medical Center, Daegu
TC Necmettin Erbakan University Meram Medical Faculty Hospital, Konya
AUSL - IRCCS Santa Maria Nuova; U.O. Day Hospital di Oncologia, Reggio Emilia
Inonu University Medical Faculty Turgut Ozal Medical Center Medical Oncology Department, Malatya
Universitätsklinikum Essen; Innere Klinik und Poliklinik für Tumorforschung, Essen
Kliniken Essen-Mitte, Evang. Huyssens-Stiftung, Klinik für Internistische Onkologie / Haematologie, Essen
Oncology Hematology Care, Cincinnati
Indiana University Health; Goshen Center for Cancer Care, Goshen
Hospital Kuala Lumpur; Jabatan Radioterapi dan Onkologi, Kuala Lumpur
Universitätsmedizin der Johannes Gutenberg-Universität Mainz; II. Medizinische Klinik, Mainz
Azlenda Ospendaliero-Universitaria Pisana; C.O. Oncologia 2, Pisa
Ospedale Misericordia E Dolce; Oncologia Medica, Prato
University Malaya Medical Centre; Clinical Oncology Unit,, Kuala Lumpur
Ospedali Riuniti Di Ancona; Oncology, Ancona
University Of Chicago Medical Center; Section Of Hematology/Oncology, Chicago
Oaxaca Site Management Organization, Oaxaca City
Universitätsklinikum Mannheim, Tagestherapiezentrum, Interdisziplinäres Tumorzentrum, Mannheim
Ospedale Casa Sollievo Della Sofferenza IRCCS, San Giovanni Rotondo
Klinikum Ludwigsburg; Studiensekretariat, Ludwigsburg
Klinik Esslingen; Klinik für Allgemeine Innere Medizin, Onkologie/Haematologie, Esslingen am Neckar
Seconda Universita' Degli Studi; Divsione Di Oncologia Medica, Napoli
Hospital Wanita dan Kanak-Kanak Sabah, Sabah
Universitätsklinikum Ulm; Zentrum für Innere Medizin Klinik für Innere Medizin I, Ulm
Comprehensive Cancer Centers of Nevada - Eastern Avenue, Las Vegas
Songklanagarind Hospital; Department of Oncology, Songkhla
Cancer Hospital Chinese Academy of Medical Sciences., Beijing
The Affiliated Hospital of Military Medical Sciences(The 307th Hospital of Chinese PLA), Beijing
Beijing Cancer Hospital, Beijing
Fuzhou General Hospital, PLA Nanjing Military Area Command, Fuzhou
General Hospital of Shenyang Military Command of PLA, Shenyang
the First Hospital of Jilin University, Changchun
Jilin Cancer Hospital, Changchun
Harbin Medical University Cancer Hospital, Harbin
Zhongshan Hospital Fudan University, Shanghai
Fudan University Shanghai Cancer Center, Shanghai
Oncology Center Sf. Nectarie, Craiova
The 81st Hospital of P.L.A., Nanjing
Changzhou First People's Hospital, Changzhou
The Affiliated Hospital of Xuzhou Medical College, Xuzhou
Affiliated Hospital of Nantong University, Nantong
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou
The 1st Affiliated Hospital of Nanchang Unversity, Nanchang
"SBI for HPE Ryazan State Medical University n.a. I.P. Pavlov of MoH of RF", Ryazan
Cardiomed Medical Center, Cluj-Napoca
Third Affiliated Hospital of Third Military Medical University, Chongqing
Clinical Oncology Dispensary of Ministry of Health of Tatarstan, Kazan'
SBI of Healthcare Samara Regional Clinical Oncology Dispensary, Samara
Henan Cancer Hospital, Zhengzhou
The First Affiliated Hospital of Zhengzhou University, Zhengzhou
Sun Yet-sen University Cancer Center, Guangzhou
Clinical Oncology Dispensary; Chemotherapy, Omsk
Euroclinic Center of Oncology SRL, Iași
The First Affiliated Hospital of The Fourth Military Medical University (Xijing Hospital), Xi'an
Clinicas Oncologicas Integradas - COI, Rio de Janeiro
Hospital Nossa Senhora da Conceicao, Porto Alegre
Hospital das Clinicas - UFRGS, Porto Alegre
Medical Research Centre, Panama City
Centro de Pesquisas Oncologicas - CEPON, Florianópolis
Hospital Sirio Libanes; Centro de Oncologia, São Paulo
Clinica de Oncologia Medica, São Paulo
Hospital A. C. Camargo; Oncologia, São Paulo
Universidade Federal de Sao Paulo - UNIFESP*X, São Paulo
Health Sciences North, Greater Sudbury
Hamilton Health Sciences - Juravinski Cancer Centre, Hamilton
London Regional Cancer Centre, London
Toronto East General Hospital; Haematology/Oncology, Toronto
Sunnybrook Health Science Centre, Toronto
Mount Sinai Hospital; Oncology, Toronto
McGill University; Glen Site; Oncology, Montreal
Hebei Medical University Fourth Hospital;(Tumor Hospital of Hebei Province), Shijiazhuang
Hospital Oncologia; Oncology, San Salvador
Docrates Cance Center, Helsinki
Universitaetsklinikum Leipzig, Universitaeres Krebszentrum Leipzig (UCCL), Leipzig
Medical Solution; Hematology, Guatemala City
Policlinico Universitario Agostino Gemelli, Rome
Aichi Cancer Center Hospital; Clinical Oncology, Aichi
Nagoya university Hospital; Gastroenterological Surgery 2, Aichi
National Cancer Center Hospital East; Gastroenterology, Chiba
National Hospital Organization Shikoku Cancer Center; Gastroenterology, Ehime
Kyushu University Hospital; Surgery and Science, Fukuoka
Gifu University Hospital; Digestive Surgery, Gifu
Hiroshima City Hiroshima Citizens Hospital; Surgery, Hiroshima
Kobe city Medical center General Hospital; Medical Oncology, Hyōgo
St.Marianna University School of Medicine hospital; Medical Oncology, Kanagawa
Kanagawa Cancer Center; Gastrointestinal Surgery, Kanagawa
Osaka International Cancer Institute;; Medical oncology and Gastrointestinal oncology, Osaka
Osaka General Medical Center; Gastroenterological Surgery, Osaka
Saitama Cancer Center; Gastroenterology, Saitama
National Cancer Center Hospital; Gastrointestinal Oncology, Tokyo
Toyama University Hospital;Gastroenterology and Hematology, Toyama
Kazakh Scientific Research Institution Of Oncology and Radiology; Chemotherapy department, Almaty
Hospital Angeles Metropolitano; Room 220, Mexico City
Academisch Medisch Centrum Universiteit Amsterdam, Amsterdam
Centro Medico Monte Carmelo, Arequipa
Hospital Sabogal; Oncology, Callao
Hosp Nacion Edgardo Rebagliati; Oncologia Medica, Jesus Maria
Clinica Internacional, Sede San Borja; Unidad de Investigacion de Clínica Internacional, Lima
Clinica San Borja, Lima
Bialostockie Ctr Onkologii; Oddzial Chemioterapii Dziennej, Bialystok
Szpital Specjalistyczny Podkarpacki Ośrodek Onkologiczny, Brzozów
Centrum Onkologii;Im. Franciszka Lukaszczyka;Onkologii, Bydgoszcz
Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kliniki Onkologii, Krakow
SPZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarawskiego, Opole
NZOZ Centrum Medyczne HCP Sp. z o.o., Poznan
Wojewódzki Szpital Specjalistyczny Nr 3, Rybnik
Narodowy Instytut Onkologii im. M. Sklodowskiej-Curie; Klinika Gastroenterologii Onkologicznej, Warsaw
Samsung Medical Center, Seoul
Seoul National Uni Hospital; Dept. of Internal Medicine/Hematology/Oncology, Seoul
Yonsei Medical Center; Dept. of Medicine , Division of Hemato-Oncology, Seoul
Asan Medical Center; Medical Oncology, Seoul
Seoul St Mary's Hospital, Seoul
Hospital General Universitario de Elche; Servicio de Oncologia, Elche
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia, Badalona
Hospital del Mar; Servicio de Oncologia, Barcelona
Hospital Univ Vall d'Hebron; Servicio de Oncologia, Barcelona
Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia, Barcelona
Hospital Duran i Reynals; Oncologia, Barcelona
National Cheng Kung University Hospital; Oncology, Tainan City
Ankara Uni School of Medicine; Medical Oncology, Ankara
Akdeniz University Medical Faculty; Medical Oncology Department, Antalya
Hoffmann-La Roche
INDUSTRY