Methylnaltrexone Use for Opioid-induced Postoperative Constipation

PHASE4CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

May 31, 2013

Primary Completion Date

May 31, 2015

Study Completion Date

May 31, 2015

Conditions
Constipation
Interventions
DRUG

Methylnaltrexone

Patient will receive methylnaltrexone on postoperative day 3 on a weight based dose and again 24 hours later if required.

DRUG

Senna, docusate sodium, bisacodyl, magnesium hydroxide, Miralax

Standard institutional bowel protocol will begin on post-operative day 1. Miralax,Docusate sodium or senna will be given on a weight-based dosing. If no bowel movement in 72 hours, bisacodyl or magnesium hydroxide will be added.

Trial Locations (1)

99203

Shriners Hospitals for Children- Spokane, Spokane

All Listed Sponsors
lead

Shriners Hospitals for Children

OTHER

NCT01773096 - Methylnaltrexone Use for Opioid-induced Postoperative Constipation | Biotech Hunter | Biotech Hunter