NCT01772758 - Cystic Fibrosis and Endothelial Function: At Rest and During Exercise | Biotech Hunter

Enrollment

64

Participants

Timeline

Start Date

August 31, 2011

Primary Completion Date

June 21, 2016

Study Completion Date

June 21, 2016

Conditions

Cystic Fibrosis

Interventions

DRUG

BH4 5mg

Kuvan® or sapropterin dihydrochloride is a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4). Subjects received an oral dose of 5 mg/kg of Kuvan® (Biomarin Pharmaceuticals Inc.)

DRUG

BH4 20mg

Kuvan® or sapropterin dihydrochloride is a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4). Subjects received an oral dose of 20 mg/kg of Kuvan® (Biomarin Pharmaceuticals Inc.)

DIETARY_SUPPLEMENT

Antioxidant Cocktail

Vitamin C (1000 mg) , Vitamin E (600 IU) , and alpha-lipoic acid (600 mg). all BID

Trial Locations (1)

30912

Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology, Augusta