Supraspinal Control of Lower Urinary Tract Function in Healthy Controls and Patients With Bladder Dysfunction

NACompletedINTERVENTIONAL
Enrollment

91

Participants

Timeline

Start Date

December 31, 2011

Primary Completion Date

July 17, 2015

Study Completion Date

December 31, 2018

Conditions
Neurogenic Lower Urinary Tract DysfunctionMultiple SclerosisOveractive BladderSpinal Cord Injury
Interventions
OTHER

fMRI

2 measurements using functional magnetic resonance imaging in a 3T scanner

OTHER

bladder filling

Repetitive retrograde bladder filling via transurethral catheter with different filling volumes using body warm saline during each of the fMRI measurements.

OTHER

bladder cooling

Retrograde bladder filling via transurethral catheter with 4-8°C saline during each of the fMRI measurements.

OTHER

additional post-treatment fMRI scan

Should NNOAB or SCI patients receive a study independent OAB therapy by their treating physician after the 2nd fMRI scan, they will be invited for an additional third fMRI scan.

Trial Locations (2)

8008

Neuro-Urology, Spinal Cord Injury Center & Research, University of Zürich, Balgrist University Hospital, Zurich

University Hospital Zürich, Zurich

All Listed Sponsors
collaborator

Swiss National Science Foundation

OTHER

collaborator

Balgrist University Hospital

OTHER

lead

University of Zurich

OTHER

NCT01768910 - Supraspinal Control of Lower Urinary Tract Function in Healthy Controls and Patients With Bladder Dysfunction | Biotech Hunter | Biotech Hunter