Cost-effectiveness of Genotype Guided Treatment With Antiplatelet Drugs in STEMI Patients: Optimization of Treatment (POPular Genetics)

PHASE4CompletedINTERVENTIONAL
Enrollment

2,700

Participants

Timeline

Start Date

June 30, 2011

Primary Completion Date

April 4, 2019

Study Completion Date

April 4, 2019

Conditions
Myocardial InfarctionSTEMI
Interventions
GENETIC

CYP2C19 genotyping

CYP2C19 genotyping will be performed in the intervention group. In patients with \*1/\*1 genotype (Extensive Metabolizer) clopidogrel will be prescribed. All patients who are carrier of a loss-to-function (\*2 or \*3) gene allel and all patients randomized to the control group will be prescribed prasugrel or ticagrelor, according to local protocol.

Trial Locations (10)

Unknown

OLV Hospital, Aalst

University of Naples Federico II, Naples

Meander Medisch Centrum, Amersfoort

OLVG, Amsterdam

Rijnstate Hospital, Arnhem

Amphia Hospital, Breda

University Medical Center Groningen, Groningen

St. Antonius Hospital, Nieuwegein

University Medical Center, Utrecht

Isala Klinieken, Zwolle

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Isala

OTHER

collaborator

Meander Medical Center

OTHER

collaborator

UMC Utrecht

OTHER

collaborator

University Medical Center Groningen

OTHER

collaborator

OLVG

NETWORK

collaborator

Onze Lieve Vrouw Hospital

OTHER

collaborator

Amphia Hospital

OTHER

collaborator

ZonMw: The Netherlands Organisation for Health Research and Development

OTHER

collaborator

Federico II University

OTHER

collaborator

Rijnstate Hospital

OTHER

lead

Vera HM Deneer

OTHER