30
Participants
Start Date
November 30, 2012
Primary Completion Date
November 30, 2016
Study Completion Date
October 31, 2017
Autologous Intrathecal Hematopoietic Stem Cells
Patients will be stimulated with granulocyte colony-stimulating factor (G-CSF) for 3 consecutive days. Bone marrow will be harvested, processed to isolate CD34+ hematopoietic stem cells and reduce red blood cells. An inoculum of 5-10 mL will then be infused intrathecally into the cerebrospinal fluid.
Observation with IDEA and CARS Scales
Participants will be observed for 6 months without active intervention. They will be evaluated using the Childhood Autism Rating Scale (CARS) and the IDEA scale at baseline, 30 days, and 180 days. After 6 months, participants may crossover to the experimental arm.
Hematology Service, Hospital Universitario Dr. Jose E. Gonzalez, Monterrey
Hospital Universitario Dr. Jose E. Gonzalez
OTHER