NCT01737671View on ClinicalTrials.gov

Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study

EARLY_PHASE1CompletedINTERVENTIONAL
Enrollment

7

Participants

Timeline

Start Date

December 27, 2012

Primary Completion Date

January 11, 2018

Study Completion Date

January 11, 2018

Conditions
Brain TumorMalignant Neoplasm of Fourth Ventricle of Brain
Interventions
PROCEDURE

Ommaya Reservoir

Surgical catheter placement into the fourth ventricle of the brain.

DRUG

Methotrexate

2 mg into fourth ventricle of the brain via the Ommaya Reservoir for 4 days. Each patient will undergo three cycles with at least two weeks between each cycle.

DRUG

Leucovorin

5 mg/square meter per dose administered every 6 hours by vein or mouth.

Trial Locations (2)

77030

Children's Memorial Hermann Hospital, Houston

University of Texas MD Anderson Cancer Center, Houston

All Listed Sponsors
lead

M.D. Anderson Cancer Center

OTHER

NCT01737671 - Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study | Biotech Hunter | Biotech Hunter