Bevacizumab With or Without Radiation Therapy in Treating Patients With Recurrent Glioblastoma

PHASE2CompletedINTERVENTIONAL
Enrollment

182

Participants

Timeline

Start Date

December 20, 2012

Primary Completion Date

September 3, 2018

Study Completion Date

December 22, 2022

Conditions
Adult Giant Cell GlioblastomaAdult GlioblastomaAdult GliosarcomaRecurrent Adult Brain Tumor
Interventions
BIOLOGICAL

bevacizumab

Staring within 14 days of randomization, IV 10mg/kg every two weeks until disease progression.

RADIATION

radiation therapy

Starting with second dose of bevacizumab, 35 Gy in 10 fractions of 3.5 Gy each delivered on consecutive treatment days (typically 5 fractions per week).

Trial Locations (31)

14642

University of Rochester, Rochester

15212

Allegheny Cancer Center at Allegheny General Hospital, Pittsburgh

17604

Lancaster General Hospital, Lancaster

19103

Radiation Therapy Oncology Group, Philadelphia

27403

Cone Health Cancer Center, Greensboro

29425

Medical University of South Carolina, Charleston

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

35294

University of Alabama at Birmingham, Birmingham

40202

Norton Health Care Pavilion - Downtown, Louisville

44203

Summa Barberton Hospital, Barberton

44304

Summa Akron City Hospital, Akron

46202

IU Health Methodist Hospital, Indianapolis

46601

Memorial Hospital of South Bend, South Bend

46804

Radiation Oncology Associates PC, Fort Wayne

48109

University of Michigan University Hospital, Ann Arbor

49007

West Michigan Cancer Center, Kalamazoo

54143

Bay Area Medical Center, Marinette

54301

Saint Vincent Hospital, Green Bay

54303

Saint Mary's Hospital, Green Bay

63110

Washington University School of Medicine, St Louis

68114

Nebraska Methodist Hospital, Omaha

85013

Arizona Oncology Services Foundation, Phoenix

85027

Arizona Oncology-Deer Valley Center, Phoenix

94598

John Muir Medical Center, Walnut Creek

96813

Queen's Medical Center, Honolulu

98902

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima

06520-8032

Yale University, New Haven

04074

Maine Medical Center- Scarborough Campus, Scarborough

01854

Lowell General Hospital, Lowell

77555-0565

University of Texas Medical Branch, Galveston

54235-1495

Door County Cancer Center, Sturgeon Bay

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Radiation Therapy Oncology Group

NETWORK

NCT01730950 - Bevacizumab With or Without Radiation Therapy in Treating Patients With Recurrent Glioblastoma | Biotech Hunter | Biotech Hunter