377
Participants
Start Date
January 24, 2013
Primary Completion Date
August 4, 2022
Study Completion Date
August 4, 2022
Epirubicin
50mg/m2 on Day 1 of each cycle only (i.e. every 21 days)
Cisplatin / Oxaliplatin
Cisplatin, 60mg/m2 on day 1 of each cycle only (i.e. every 21 days). OR Oxaliplatin,130 mg/m2 on Day 1 of each cycle (i.e. every 21 days) The choice between administering Cisplatin or Oxaliplatin is at the discretion of the investigator.
5 Flourouracil/ Capecitabine
5-Flourouracil 200 mg/m2/day every day for 21 days OR Capecitabine 625 mg/m2 twice daily orally). The choice between administering 5 Flourouracil or Capecitabine is at the discretion of the investigator.
(41.4 Gy/23 fractions)
Patient will receive 4.5 weeks of radiation therapy (41.4 Gy/23 fractions).
Paclitaxel
50mg/ m2 Paclitaxel dose administered on Days 1, 8, 15,22 and 29. Dexamethasone, Chlorphenamine and Ranitidine dose given per local standard practice. NACL infusion per local standard practice. Ondansetron dose given per local standard practice on Days 1, 8, 15, 22 and 29.
Carboplatin
Dose determined as per calculation, infused on Days 1, 8, 15, 22 and 29
Docetaxel
Docetaxel, 50 mg/m², day 1 of each cycle (i.e. every 14 days)
Oxaliplatin
85 mg/m², day 1 of each cycle (i.e. every 14 days)
Leucovorin
200 mg/m², day 1 of each cycle (i.e. every 14 days).
5-Fluorouracil
2600 mg/m² Day 1 of each cycle (i.e. every 14 days) Dexamethasone or equivalent, 8mg, twice daily, Day before, day of and day after OR administered as per standard practice
Rigshospitalet, Blegdamsvej 9
Centre Hospitalier Régional, Universitaire de Lille 2 Avenue Oscar Lambret, 59000, Lille
Cork University Hospital, Cork
Beaumont Hospital, Dublin
SLRON- St Luke's Radiation Oncology Network, Dublin
St. James's Hospital, Dublin
University Hospital Galway, Galway
Karolinska Institutet and Karolinska University Hospital, Stockholm
The Royal Bournemouth Hospital, The Royal Bournemouth and Christchurch Hospitals NHS Foundation
Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Box 279(s4), Cambridge Biomedical Camp
Velindre Cancer Centre, Velindre NHS Trust, Velindre Road, Whitchurch
University Hospitals Coventry & Warwickshire, Clifford Bridge Road, Walsgrave
Hull and East Yorkshire Hospitals NHS Trust, Castle Hill Hospital,, Cottingham
Portsmouth Hospitals NHS Trust, Southwick Hill Road, Cosham
Mount Vernon Cancer Centre, E & N Hertfordshire NHS Trust, Rickmansworth Road, Northwood
Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Hucknall Road
Oxford University Hospital NHS Trust Churchill Hospital, Headington
University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Division A Cancer Care, Mp307, T
Royal Surrey County Hospital, Guildford
Worcestershire Royal Hospital, Worcestershire Oncology Centre, Charles Hastings Way
Belfast Health and Social Care Trust, Northern Ireland Cancer Centre, Belfast CityHospital, Belfast
The Clatterbridge Cancer Centre NHS Foundation Trust, Birkenhead, Wirral
University Hospitals Bristol NHS Foundation Trust, Bristol
University Hospital Plymouth NHS Trust, Derriford Hospital, Derriford Road, Crownhill, Plymouth
NHS Lothian, Edinburgh Cancer Centre,, Edinburgh
Beatson West of Scotland Cancer Centre, Glasgow, 1056 Great Western Road
Imperial College Healthcare NHS Trust St Mary's Hospital, London
The Newcastle upon Tyne Hospital NHS Foundation TrustFreeman Hospital, Freeman Road, High Heaton, Newcastle upon Tyne
Royal Preston Hospital, Sharoe Garoo Lane, Fulwood, Preston
Southampton Clinical Trials Unit
UNKNOWN
Region H Rigshospitalet
UNKNOWN
Centre Hospitalier Régional, Universitaire de Lille
UNKNOWN
Cancer Trials Ireland
NETWORK