470
Participants
Start Date
November 30, 2012
Primary Completion Date
October 31, 2015
Study Completion Date
October 31, 2015
Tigecycline
every 12 hours (an initial intravenous dose of 100 mg followed by 50 mg twice a day approximately every 12 hours) and placebo intravenous doses every 12 hours beginning 6 hours after the initial intravenous dose of tigecycline for at least for 5 days and up to 14 days.
Imipenem/cilastatin
every 6 hours intravenously, and the imipenem/cilastatin will be dosed by 500mg/500mg for the subjects with creatinine clearance equal or above 71ml/min/1.73m2 or dose will be adjusted by Schedule of Study Drug Administration for Subjects with Renal Impairment.
China Meitan General Hospital/General Surgery Department, Beijing
Department of General Surgery,Beijing Shijitan Hospital,Capital Medical University, Beijing
Department of Hepatobiliary Surgery, Peking University People's Hospital, Xicheng District
Navy General Hospital PLA China/Genaral Surgery Department, Beijing
Peking University Third Hospital, Beijing
Department of General Surgery, Peking Union Medical College Hospital, Beijing
Jilin Province People's Hospital, Changchun
The First Hospital of Jilin University/Surgery, Changchun
The Second Hospital of Jilin University, Changchun
Institute of Antibiotics, Hua Shan Hospital, Fudan University, Shanghai
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai
Shanghai Fengxian District Central Hospital, Department of Surgery, Shanghai
Zhongshan Hospital Affiliated to Fudan University Qingpu Branch, Department of Surgery,, Shanghai
The Affiliated Jiangyin Hospital of Southeast University Medical College, General Surgery Department, Jiangyin
The Second Affiliated Hospital of Soochow University, Suzhou
The First Affiliated Hospital of Soochow University, Suzhou
Yangzhou No.1 People's Hospital, Yangzhou
Anqing City Hospital, Anqing
Binzhou Medical University Hospital, Binzhou
Tianjin Union Medical Center, Tianjin
Department of General Surgery, Tianjin Medical University General Hospital, Tianjin
Tianjin Nankai Hospital, Tianjin
The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou
Taizhou Hospital of Zhejiang Province, Linhai
Lishui People's Hospital/Intensive Care Unit, Lishui
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou
Zhongshan Hospital Xiamen University, Xiamen
Zhangzhou Municipal Hospital of Fujian Province, Zhangzhou
Xiangya Hospital Central-South University/General Surgery, Changsha
The Third Xiangya Hospital of Central South University/Department of General Surgery, Changsha
The Third Hospital of Changsha/Department of Surgery, Changsha
Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan
Zhongnan Hospital of Wuhan University/Intensive Care Unit, Wuhan
Department of General Surgery, the First Affiliated Hospital Of Guangzhou Medical University, Guangzhou
The First Affiliated Hospital of JiNan University/General Surgery, Guangzhou
The First Hospital of Shantou University School of Medicine, Shantou
Shenzhen Second People's Hosptial/Department of hepatobiliary surgery, Shenzhen
Affiliated Hospital of Guilin Medical University, Guilin
HaiKou Municipal People's Hospital, Haikou
Hainan Provincial People's Hospital, Haikou
The Third People's Hospital of Hainan Province/department of general surgery, Sanya
Department of General Surgery, Sichuan Provincial People's Hospital, Chengdu
General Hospital of Chengdu Military Region of PLA, Chengdu
First people's Hospital of Kunming, Kunming
Qinghai Provincial People's Hospital, Xining
Baotou Central Hospital, Baotou
Lead Sponsor
Pfizer
INDUSTRY