Optimization of Bevacizumab Scheduling With Chemotherapy for Metastatic Colorectal Cancer

5 mg/kg every 2 weeks for up to 24 weeks. After 24 weeks, those patients without disease progression will receive bevacizumab 7.5 mg/kg every 3 weeks until progression of disease or unacceptable toxicity.

85mg/m2 IV every 2 weeks for up to 24 weeks

200 mg/m2 IV before 5-fluorouracil infusion, every 2 weeks up to 24 weeks

400 mg/m2 IV bolus followed by 2400 mg/m2 IV infusion over 46 hours, every 2 weeks for up to 24 weeks (given in mFOLFOX-6 schedule)

1000mg/m2 by mouth, twice a day for 10 days, every 2 weeks for up to 24 weeks(given in mOXXEL schedule)