97
Participants
Start Date
December 31, 2012
Primary Completion Date
December 31, 2017
Study Completion Date
December 31, 2017
TPA (Tissue Plasminogen Activator)
Intrapleural administration of tPA 4 mg in 10 ml (≤10 kg) or 20 ml (\>10 kg) normal saline once daily for 3 days
DNase
Intrapleural administration of DNase 5 mg diluted to 10 ml (≤10 kg) or 20 ml (\>10 kg) normal saline once daily for 3 days
Placebo
Intrapleural administration of normal saline 10 ml (≤10 kg) or 20 ml (\>10 kg)
Alberta Children's Hospital, Calgary
British Columbia Children's Hospital, Vancouver
McMaster Children's Hospital, Hamilton
Children's Hospital of Eastern Ontario, Ottawa
The Hospital for Sick Children(SickKids), Toronto
CHU Sainte Justine, Montreal
Canadian Institutes of Health Research (CIHR)
OTHER_GOV
Children's Hospital of Eastern Ontario
OTHER
St. Justine's Hospital
OTHER
Unity Health Toronto
OTHER
The Physicians' Services Incorporated Foundation
OTHER
McMaster Children's Hospital
OTHER
British Columbia Children's Hospital
OTHER
The Hospital for Sick Children
OTHER