NCT01715922 - Study Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan Africa | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

May 31, 2012

Primary Completion Date

September 30, 2015

Study Completion Date

September 30, 2016

Conditions

Cryptococcal MeningitisHIV

Interventions

DRUG

Fluconazole

Induction treatment for 2 weeks: Fluconazole (1600mg/j) Consolidation treatment for 8 weeks: fluconazole (800 mg/j)

DRUG

Flucytosine

Flucytosine (100 mg/kg/j) for 2 weeks

PROCEDURE

lumbar punctures

lumbar punctures to control intracranial pressure

Trial Locations (7)

CHU Kamenge, Bujumbura

Hôpital Prince Régent Charles, Bujumbura

Hôpital général, Bururi

Hôpital général, Kayanza

Hôpital général, Muyinga

Service de Maladies Infectieuses & Tropicales - Hôpital Triechville, Abidjan

Service de Neurologie - Hôpital Cocody, Abidjan