Effect of P-glycoprotein Inhibition on Lenalidomide Pharmacokinetics in Healthy Males

25 mg Lenalidomide capsule will be administered orally once in the first period, and once with Quinidine in the second period

300 mg of Quinidine will be administered orally every 12 hours for 1 day followed by 600 mg of Quinidine administered orally every 12 hours for the next 4 consecutive days

25 mg/mL injection of Temsirolimus will be given directly into the vein over 30 minutes once in the second period and once with Lenalidomide in the third period.

Just before Temsirolimus is given, 25 mg of Diphenhydramine (Benadryl) will be given directly into the vein to decrease chances of an allergic reaction to Temsirolimus.