Spironolactone for Pulmonary Arterial Hypertension

PHASE2RecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

January 10, 2014

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Pulmonary Arterial Hypertension
Interventions
DRUG

Spironolactone

Initial dose, 25 mg (pink capsule) orally, daily. If well tolerated at 7-9 wks then increased to 50 mg (brown capsule) daily.

DRUG

Placebo

Initial dose, pink sugar capsule, daily. If well tolerated at 7-9 wks then changed to brown sugar capsule, daily.

Trial Locations (1)

20892

RECRUITING

National Institutes of Health Clinical Center, Bethesda

Sponsors
All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

collaborator

University of Pennsylvania

OTHER

collaborator

University of Maryland, Baltimore

OTHER

collaborator

Medstar Health Research Institute

OTHER

collaborator

New England Medical Center, Tufts University School of Medicine

UNKNOWN

lead

National Institutes of Health Clinical Center (CC)

NIH