142
Participants
Start Date
March 15, 2013
Primary Completion Date
December 1, 2020
Study Completion Date
September 21, 2022
IMRT
Intensity modulated radiation therapy (IMRT), 35 fractions over 6 weeks, 6 fractions per week for 5 weeks and 5 fractions per week for 1 week, 2 Gy per fraction to total dose of 70 Gy
Cisplatin
100 mg/m\^2 administered intravenously on days 8 and 29
placebo
1500 mg placebo daily by mouth or by feeding tube starting 7 days before IMRT for 7 weeks prior to and during IMRT and 3 months after completion of IMRT
Lapatinib
1500 mg lapatinib by mouth or by feeding tube daily starting 7 days before IMRT for 7 weeks prior to and during IMRT and 3 months after completion of IMRT
Fox Chase Cancer Center Buckingham, Furlong
Emory University, Atlanta
University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham
James Graham Brown Cancer Center at University of Louisville, Louisville
Ohio State University Medical Center, Columbus
University Hospitals of Cleveland, Cleveland
Medical College of Wisconsin, Milwaukee
University of Wisconsin Comprehensive Cancer Center, Madison
University of Oklahoma Health Sciences Center, Oklahoma City
University of Texas Southwestern Medical School, Dallas
University of California, San Diego, La Jolla
University of California San Francisco, San Francisco
Sutter General Hospital, Sacramento
Yale University, New Haven
University of Texas - MD Anderson Cancer Center, Houston
McGill Cancer Centre at McGill University, Montreal
Collaborators (2)
GlaxoSmithKline
INDUSTRY
Novartis
INDUSTRY
Radiation Therapy Oncology Group
NETWORK