Study of Alirocumab (REGN727/SAR236553) in Patients With heFH (Heterozygous Familial Hypercholesterolemia) Who Are Not Adequately Controlled With Their LMT (Lipid-Modifying Therapy)

PHASE3CompletedINTERVENTIONAL
Enrollment

249

Participants

Timeline

Start Date

December 31, 2012

Primary Completion Date

May 31, 2014

Study Completion Date

January 31, 2015

Conditions
Heterozygous Familial Hypercholesterolemia
Interventions
DRUG

LMT (atorvastatin, simvastatin, or rosuvastatin)

DRUG

alirocumab

Alirocumab administered as a subcutaneous (SC) injection of 1 mL into the abdomen, thigh, or outer area of the upper arm.

DRUG

Placebo

Placebo matched to alirocumab administered as a SC injection of 1 mL into the abdomen, thigh, or outer area of the upper arm.

Trial Locations (24)

Unknown

Hradec Králové

Prague

Trutnov

Vyškov

Alkmaar

Amsterdam

Apeldoorn

Enschede

Goes

Groningen

Hoogeveen

Hoorn

Rotterdam

Sittard- Geleen

Utrecht (2 Locations)

Venlo

Waalwijk

Oslo

Cardiff

London

Manchester

Middlesex

Newcastle upon Tyne

West Bromwich

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Sanofi

INDUSTRY

lead

Regeneron Pharmaceuticals

INDUSTRY