A Study of the Safety and Efficacy of Glimepiride, Gliclazide, Repaglinide or Acarbose When Added to Sitagliptin + Metformin Combination Therapy in Chinese Participants With Diabetes (MK-0431-313)

PHASE4CompletedINTERVENTIONAL
Enrollment

5,570

Participants

Timeline

Start Date

November 8, 2012

Primary Completion Date

April 17, 2015

Study Completion Date

April 17, 2015

Conditions
Type 2 Diabetes Mellitus
Interventions
DRUG

Metformin

Metformin, 500 mg or 850 mg oral tablets, twice or three times a day (BID or TID) for a total dose of at least 1500 mg daily; administered with food.

DRUG

Sitagliptin

Sitagliptin, 100 mg oral tablet, once daily (QD); administered with or without food

DRUG

Acarbose

Acarbose, 50 mg oral tablets, TID (150 mg total daily dose); administered with the first bite of each main meal.

DRUG

Repaglinide

Repaglinide, 0.5 mg and/or 1 mg oral tablets, TID (up to 16 mg daily); administered within 30 minutes of each meal.

DRUG

Glimepiride

Glimepiride, 1 mg and/or 2 mg oral tablets, QD (up to 6 mg daily); administered before the first main meal of the day

DRUG

Gliclazide

Gliclazide, 30 mg oral tablets, QD or BID (30 mg to 120 mg total daily dose); administered with meal.

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT01709305 - A Study of the Safety and Efficacy of Glimepiride, Gliclazide, Repaglinide or Acarbose When Added to Sitagliptin + Metformin Combination Therapy in Chinese Participants With Diabetes (MK-0431-313) | Biotech Hunter | Biotech Hunter