Open-label, Phase II, Study of Everolimus Plus Letrozole in Postmenopausal Women With ER+, HER2- Metastatic or Locally Advanced Breast Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

202

Participants

Timeline

Start Date

March 7, 2013

Primary Completion Date

December 17, 2015

Study Completion Date

January 13, 2021

Conditions
Hormone Receptor Positive Breast Cancer
Interventions
DRUG

Everolimus

Everolimus was self-administered as a daily dose of 10mg (two 5mg tablets) taken orally continuously until progression of disease, unacceptable toxicity or withdrawal of consent.

DRUG

Letrozole

1st line study treatment: Letrozole was self administered as a daily dose of 2.5mg continuously until disease progression or any other reason for which the patient might be discontinued

DRUG

Exemestane

2nd Line Study Treatment: Exemestane was self administered as a daily dose of 25mg taken orally continuously until disease progression or any other reason for which the patient might be discontinued

DRUG

Alcohol-free dexamethasone mouth rinse (Stomatitis sub-study)

Alcohol-free 0.5mg/5ml dexamethasone oral solution was self-administered at a daily dose of 10ml 3 times per day (participants with confirmed stomatitis who entered the stomatitis sub-study).

DRUG

Standard of care to treat stomatitis (Stomatitis sub-study)

Standard of care used to treat stomatitis at the patient's center (participants with confirmed stomatitis who entered the stomatitis sub-study).

Trial Locations (52)

5700

Novartis Investigative Site, Gyula

5800

Novartis Investigative Site, Maastricht

6000

Novartis Investigative Site, Kecskemét

6300

Novartis Investigative Site, Santa Rosa

7100

Novartis Investigative Site, Szekszárd

10032

Columbia University Medical Center- New York Presbyterian Columbia, New York

10330

Novartis Investigative Site, Bangkok

10400

Novartis Investigative Site, Bangkok

10700

Novartis Investigative Site, Bangkok

13790

Broome Oncology SC, Johnson City

15006

Novartis Investigative Site, A Coruña

25030

Novartis Investigative Site, Besançon

27403

Cone Health Cancer Center, Greensboro

33076

Novartis Investigative Site, Bordeaux

34303

Novartis Investigative Site, Istanbul

35040

Novartis Investigative Site, Izmir

35294

University of Alabama Comprehensive Cancer Center SC-2, Birmingham

37007

Novartis Investigative Site, Salamanca

40202

Norton Healthcare Inc SC, Louisville

44277

Novartis Investigative Site, Nantes

46010

Novartis Investigative Site, Valencia

54000

Novartis Investigative Site, Nancy

69373

Novartis Investigative Site, Lyon

75904

East Texas Hematology Clinic SC, Lufkin

78157

Novartis Investigative Site, Le Chesnay

83400

Novartis Investigative Site, Hyères

84106

Utah Cancer Specialists Dept.of Utah Cancer Spec. (3), Salt Lake City

85234

Banner MD Anderson Cancer Center, Gilbert

87106

University of New Mexico Hospital SC, Albuquerque

90806

Breastlink Medical Group Dept. of BreastlinkResearchGrp, Long Beach

92354

Loma Linda University Loma Linda, Loma Linda

60068-0736

Oncology Specialists, SC Advocate Medical Group-Niles, Park Ridge

66606-169

St. Francis Health Comprehensive Cancer Center, Topeka

01199

Baystate Medical Center SC-2, Springfield

07039

Saint Barnabas Medical Center CancerCenter of Saint Barnabas, Livingston

S2000KZE

Novartis Investigative Site, Rosario

90035-003

Novartis Investigative Site, Porto Alegre

01317-002

Novartis Investigative Site, São Paulo

04014-002

Novartis Investigative Site, São Paulo

467-8602

Novartis Investigative Site, Nagoya

003-0804

Novartis Investigative Site, Sapporo

028-3695

Novartis Investigative Site, Shiwa-gun

216-8511

Novartis Investigative Site, Kawasaki

860-8556

Novartis Investigative Site, Kumamoto

1400-038

Novartis Investigative Site, Lisbon

1649-035

Novartis Investigative Site, Lisbon

4200-072

Novartis Investigative Site, Porto

01812

Novartis Investigative Site, Seoul

06273

Novartis Investigative Site, Seoul

06351

Novartis Investigative Site, Seoul

07059

Novartis Investigative Site, Antalya

BA1 3NG

Novartis Investigative Site, Bath

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY