495
Participants
Start Date
January 8, 2013
Primary Completion Date
May 9, 2014
Study Completion Date
July 21, 2019
Placebo
Placebo supplied as tablets
Vemurafenib
Vemurafenib supplied as tablets
Cobimetinib
Cobimetinib supplied as tablets
Institut Jules Bordet; Department of Medical Oncology, Brussels
Auckland City Hospital, Auckland
Medizinische Universität Wien, Vienna
Orszagos Onkologiai Intezet, Budapest
Cliniques Universitaires St-Luc, Brussels
Chris O'Brien Lifehouse, Camperdown
Princess Alexandra Hospital, Woolloongabba
Melanoma Institute Australia, North Sydney
Lake Macquarie Private Hospital, Gateshead
Lismore Base Hospital; Cancer Care & Haematology Unit, Lismore
UZ Antwerpen, Edegem
Rhode Island Hospital; Investigational Services, Providence
Peter MacCallum Cancer Centre-East Melbourne, Melbourne
Inselspital-Universitaetsspital Bern, Bern
Austin Hospital, Heidelberg
Landesklinikum St. Pölten, Sankt Pölten
The Alfred Hospital, Prahan
Peninsula and South Eastern Haematology and Oncology Group, Frankston
Waikato Hospital, Hamilton
Jessa Zkh (Campus Virga Jesse), Hasselt
CHU Sart-Tilman, Liège
Ordensklinikum Linz Elisabethinen, Linz
Royal Brisbane and Women's Hospital, Herston
Greenslopes Private Hospital, Greenslopes
Royal Adelaide Hospital; Hepatology, Adelaide
Ashford Cancer Centre, Ashford SA
Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaza, Gyula
Fiona Stanley Hospital, Murdoch
Szegedi Tud.Egyetem Szent-Gyorgyi Albert Klin.Kozp., Szeged
Royal Hobart Hospital, Hobart
Kantonsspital Graubuenden, Chur
Launceston General Hospital; Gastroenterology Research, Launceston
Somogy Megyei Kaposi Mor Oktato Korhaz, Pécs
AZ Delta (Campus Rumbeke), Roeselare
Hopital de la Timone, Marseille
University of Pittsburgh, Pittsburgh
Complexo Hospitalario Universitario de Santiago, Santiago de Compostela
Istituto Nazionale per la Ricerca sul Cancro di Genova, Genoa
St. Luke's University Health network, Bethlehem
Thomas Jefferson University Hospital, Philadelphia
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Universitätsklinikum Hamburg-Eppendorf, Hamburg
CHU de Dijon - Hopital le Bocage, Dijon
Elbekliniken Buxtehude GmbH, Buxtehude
Universitaetsklinikum Schleswig-Holstein - Campus Kiel; Klinik fuer Allgemeine Innere Medizin, Kiel
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII), Bergamo
Asst Degli Spedali Civili Di Brescia, Brescia
Novant Health Oncology Specialists, Winston-Salem
MD Anderson Cancer Center, Madrid
Hospital Universitario 12 de Octubre, Madrid
Medizinische Hochschule Hannover, Hanover
Clinica Universitaria de Navarra, Pamplona
Orlando Health Inc., Orlando
Groupe Hospitalier Saint André - Hôpital Saint André, Bordeaux
Mount Sinai Medical Center, Miami Beach
Florida Cancer Specialists - Broadway, Fort Myers
Hopital Saint Eloi, Montpellier
Centre Eugene Marquis; Service d'oncologie, Rennes
IOV - Istituto Oncologico Veneto IRCCS, Padua
University of Alabama at Birmingham, Birmingham
Universitätsmedizin Göttingen, Göttingen
Vanderbilt University Medical Center, Nashville
Centre Hospitalier Universitaire de Grenoble - Albert Michallon, La Tronche
A.O.U. Policlinico di Modena, Modena
U of L - Physicians Pulmonology; Dept of Neuroradiology and Dept of Diagnostic Radiology, Louisville
Hospital Universitario Virgen Macarena, Seville
CHU NANTES - Hôtel Dieu; Pharmacy, Nantes
University Hospitals of Cleveland, Cleveland
St. Josef-Hospital; Studienambulanz, Bochum
Universitätsklinikum Essen, Essen
Hospital General Universitario de Valencia, Valencia
Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori, Meldola
Fachklinik Hornheide, Münster
Hospital Universitario Miguel Servet, Zaragoza
Universitaetsklinikum Koeln; Hematology/Oncology, Cologne
Hopital Robert Debre; DERMATOLOGIE, Reims
A.O.U. Senese Policlinico Santa Maria Alle Scotte, Siena
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz, Mainz
Hopital Claude Huriez - CHU Lille, Lille
Northwestern Center For Clinical Research, Chicago
CHU Clermont Ferrand - Hôpital d'Estaing, Clermont-Ferrand
Washington University School of Medicine; Dept of Medicine/Div of Medical Oncology, St Louis
Klinikum Mannheim GmbH Universitätsklinikum, Mannheim
Universitätsklinikum Heidelberg, Heidelberg
Centre Hospitalier Lyon Sud, Pierre-Bénite
Istituto Tumori Giovanni Paolo II IRCSS; Ospedale Oncologico Bari, Bari
Universitätsklinikum Tübingen, Tübingen
Universitaetsklinikum Freiburg, Freiburg im Breisgau
University Of Colorado, Aurora
Istituto Nazionale Tumori Fondazione G. Pascale, Napoli
Klinikum der Ludwigs-Maximilians-Universitaet Muenchen, München
The Angeles Clinic and Research Institute - W LA Office, Los Angeles
Hôpital Ambroise Paré - Boulogne-Billancourt; Respiratory, Boulogne-Billancourt
Universitaetsklinikum Regensburg, Regensburg
Sutter Pacific Medical Foundation, Santa Rosa
University of California Davis Health System, Sacramento
Universitätsklinikum Wurzburg, Würzburg
Helios Klinikum Erfurt, Erfurt
"FSBSI N. N. Blokhin Russian Cancer Research Center", Moscow
Moscow city oncology hospital #62 of Moscow Healthcare Department, Moscow
Pyatigorsky Oncologic Dispensary, Pyatigorsk
BHI of Omsk region Clinical Oncology Dispensary, Omsk
TSBHI Altai Territorial oncological dispensary, Barnaul
Rambam Health Care Campus, Haifa
Rabin Medical Center-Beilinson Campus;Hematology-Oncology, Petah Tikva
Chaim Sheba Medical Center, Ramat Gan
Tel Aviv Sourasky MC, Dana children's hospital;Oncology Division, Tel Aviv
Soroka Medical Center; Oncology Dept, Beersheba
HADASSAH UNIVERSITY HOSPITAL, EIN KAREM; Oncology, Jerusalem
Uni of Kansas Medical Center; Dept of Neurology, Kansas City
Dartmouth-Hitchcock Medical Center; Department of Medicine, Lebanon
Royal Darwin Hospital, Casuarina
BC Cancer Agency Vancouver Island Cancer Centre, Victoria
Juravinski Cancer Clinic; Department of Oncology, Hamilton
The Ottawa Hospital Cancer Center; General Campus, Ottawa
Toronto Sunnybrook Hospital, Toronto
Princess Margaret Hospital; Department of Med Oncology, Toronto
London Health Sciences Centre · Victoria Hospital;Department of Pediatrics, London
McGill University Health Centre/Glen Site / Royal Victoria Hospital, Montreal
Masarykuv onkologicky ustav, Brno
Fakultni nemocnice Hradec Kralove, Hradec Králové
Fakultní nemocnice Olomouc, Olomouc
Fakultni nemocnice Ostrava, Ostrava - Poruba
Multiscan s.r.o., Pardubice
Fakultni nemocnice Kralovske Vinohrady, Prague
Vseobecna fakultni nemocnice v Praze, Prague
Fakultni nemocnice Motol; Neurologicka klinika, Prague
Nemocnice Na Bulovce, Prague
CHU Nice - Hopital de l'Archet 2, Nice
"Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden", Dresden
SRH Wald-Klinikum Gera; Klinik für Hautkrankheiten und Allergologie, Gera
Istituto Nazionale Tumori Regina Elena IRCCS, Rome
Amsterdam UMC Location VUMC, Amsterdam
Leids Universitair Medisch Centrum; Cardiology, Leiden
Maastricht University Medical Center, Maastricht
Radiumhospitalet, Oslo
Hospital Clínic i Provincial de Barcelona, Barcelona
Länssjukhuset Ryhov, Jönköping
Skånes Universitetssjukhus, Lund
Sahlgrenska Sjukhuset, Mölnlycke
Akademiska Sjukhuset, Uppsala
Bristol Haematology and Oncology Centre, Bristol
Addenbrooke's Hospital, Cambridge
Velindre Cancer Centre, Cardiff
Western General Hospital, Edinburgh
Beatson West of Scotland Cancer Centre, Glasgow
The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool
Barts and the London NHS Trust., London
St George's Hospital; Courtyard Clinic, London
Royal Marsden Hospital - Fulham, London
Royal Marsden Hospital - London, London
Freeman Hospital, Newcastle upon Tyne
Nottingham University Hospitals; QMC Campus, Nottingham
Southampton General Hospital, Southampton
Royal Cornwall Hospital, Truro
New Cross Hospital, Wolverhampton
Hoffmann-La Roche
INDUSTRY