Tivantinib With or Without Erlotinib Hydrochloride in Treating Patients With Metastatic or Locally Advanced Kidney Cancer That Cannot Be Removed by Surgery

PHASE2CompletedINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

August 20, 2012

Primary Completion Date

April 30, 2017

Study Completion Date

April 30, 2017

Conditions
Recurrent Renal Cell CarcinomaStage III Renal Cell CancerStage IV Renal Cell CancerType 1 Papillary Renal Cell CarcinomaType 2 Papillary Renal Cell Carcinoma
Interventions
DRUG

Erlotinib Hydrochloride

150 mg (1 tablet) by mouth on days 1-28, once daily, until disease progression

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Tivantinib

360 mg (3 tablets) by mouth, Twice daily (720 mg total daily dose) on days 1-28, until disease progression

Trial Locations (214)

10032

Columbia University/Herbert Irving Cancer Center, New York

10940

Orange Regional Medical Center, Middletown

12801

Glens Falls Hospital, Glens Falls

14642

University of Rochester, Rochester

16801

Geisinger Medical Group, State College

17822

Geisinger Medical Center, Danville

18201

Geisinger Medical Center-Cancer Center Hazleton, Hazleton

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

20007

MedStar Georgetown University Hospital, Washington D.C.

20016

Sibley Memorial Hospital, Washington D.C.

20037

George Washington University Medical Center, Washington D.C.

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

28501

Kinston Medical Specialists PA, Kinston

28677

Iredell Memorial Hospital, Statesville

37232

Vanderbilt University/Ingram Cancer Center, Nashville

39216

University of Mississippi Medical Center, Jackson

43015

Grady Memorial Hospital, Delaware

43050

Knox Community Hospital, Mount Vernon

43055

Licking Memorial Hospital, Newark

43081

Saint Ann's Hospital, Westerville

43130

Fairfield Medical Center, Lancaster

43214

Riverside Methodist Hospital, Columbus

43215

Columbus NCI Community Oncology Research Program, Columbus

Grant Medical Center, Columbus

43219

The Mark H Zangmeister Center, Columbus

43222

Mount Carmel Health Center West, Columbus

43228

Doctors Hospital, Columbus

43701

Genesis Healthcare System Cancer Care Center, Zanesville

45331

Wayne Hospital, Greenville

45373

Upper Valley Medical Center, Troy

45385

Greene Memorial Hospital, Xenia

45405

Grandview Hospital, Dayton

45406

Good Samaritan Hospital - Dayton, Dayton

45409

Miami Valley Hospital, Dayton

45415

Samaritan North Health Center, Dayton

45420

Dayton NCI Community Oncology Research Program, Dayton

45429

Kettering Medical Center, Kettering

45505

Springfield Regional Medical Center, Springfield

45601

Adena Regional Medical Center, Chillicothe

45662

Southern Ohio Medical Center, Portsmouth

45750

Marietta Memorial Hospital, Marietta

45801

Saint Rita's Medical Center, Lima

45840

Blanchard Valley Hospital, Findlay

46107

Franciscan Saint Francis Health-Beech Grove, Beech Grove

46237

Franciscan Health Indianapolis, Indianapolis

47374

Reid Health, Richmond

48060

Lake Huron Medical Center, Port Huron

48093

Saint John Macomb-Oakland Hospital, Warren

48106

Michigan Cancer Research Consortium NCORP, Ann Arbor

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48124

Beaumont Hospital-Dearborn, Dearborn

48154

Saint Mary Mercy Hospital, Livonia

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48236

Saint John Hospital and Medical Center, Detroit

48341

Saint Joseph Mercy Oakland, Pontiac

48439

Genesys Regional Medical Center, Grand Blanc

48502

Hurley Medical Center, Flint

48503

Genesys Hurley Cancer Institute, Flint

48532

Genesys Regional Medical Center-West Flint Campus, Flint

48601

Saint Mary's of Michigan, Saginaw

48912

Sparrow Hospital, Lansing

49001

Borgess Medical Center, Kalamazoo

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49201

Allegiance Health, Jackson

51101

Siouxland Regional Cancer Center, Sioux City

51104

Mercy Medical Center-Sioux City, Sioux City

Saint Luke's Regional Medical Center, Sioux City

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

54017

Cancer Center of Western Wisconsin, New Richmond

54601

Gundersen Lutheran Medical Center, La Crosse

55082

Lakeview Hospital, Stillwater

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55350

Hutchinson Area Health Care, Hutchinson

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Metro Minnesota Community Oncology Research Consortium, Saint Louis Park

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview-Southdale Hospital, Edina

56073

New Ulm Medical Center, New Ulm

56201

Rice Memorial Hospital, Willmar

57701

Rapid City Regional Hospital, Rapid City

60035

Hematology Oncology Associates of Illinois-Highland Park, Highland Park

60048

NorthShore Hematology Oncology-Libertyville, Libertyville

60076

Hematology Oncology Associates of Illinois - Skokie, Skokie

60141

Hines Veterans Administration Hospital, Hines

60153

Loyola University Medical Center, Maywood

60611

Hematology and Oncology Associates, Chicago

Northwestern University, Chicago

60714

Illinois Cancer Specialists-Niles, Niles

60901

Presence Saint Mary's Hospital, Kankakee

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63141

Mercy Hospital Saint Louis, St Louis

Saint Louis-Cape Girardeau CCOP, St Louis

63703

Saint Francis Medical Center, Cape Girardeau

64068

Liberty Radiation Oncology Center, Liberty

64086

Saint Luke's East - Lee's Summit, Lee's Summit

64108

Truman Medical Center, Kansas City

64111

Saint Luke's Hospital of Kansas City, Kansas City

64116

North Kansas City Hospital, Kansas City

64118

Heartland Hematology and Oncology Associates Incorporated, Kansas City

64132

Research Medical Center, Kansas City

64506

Heartland Regional Medical Center, Saint Joseph

64507

Saint Joseph Oncology Inc, Saint Joseph

66044

Lawrence Memorial Hospital, Lawrence

66112

Providence Medical Center, Kansas City

66160

University of Kansas Cancer Center, Kansas City

66208

Kansas City NCI Community Oncology Research Program, Prairie Village

66209

Menorah Medical Center, Overland Park

66213

Saint Luke's South Hospital, Overland Park

66606

Saint Francis Hospital and Medical Center - Topeka, Topeka

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas - Chanute, Chanute

66762

Via Christi Hospital-Pittsburg, Pittsburg

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Associates In Womens Health, Wichita

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Cancer Center of Kansas - Wichita, Wichita

Via Christi Regional Medical Center, Wichita

Wichita NCI Community Oncology Research Program, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

Salina Regional Health Center, Salina

67460

Cancer Center of Kansas - McPherson, McPherson

67502

Hutchinson Regional Medical Center, Hutchinson

67530

Saint Rose Ambulatory and Surgery Center, Great Bend

67601

Hays Medical Center, Hays

67801

Cancer Center of Kansas - Dodge City, Dodge City

67905

Cancer Center of Kansas-Liberal, Liberal

68114

Nebraska Methodist Hospital, Omaha

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75246

Baylor University Medical Center, Dallas

78209

Audie L Murphy Veterans Affairs Hospital, San Antonio

78229

Cancer Therapy and Research Center at The UT Health Science Center at San Antonio, San Antonio

University Hospital, San Antonio

University of Texas Health Science Center at San Antonio, San Antonio

80045

University of Colorado Cancer Center - Anschutz Cancer Pavilion, Aurora

83642

Idaho Urologic Institute-Meridian, Meridian

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

85704

University of Arizona Cancer Center-Orange Grove Campus, Tucson

85719

University of Arizona Cancer Center-North Campus, Tucson

85724

The University of Arizona Medical Center-University Campus, Tucson

89102

University Medical Center of Southern Nevada, Las Vegas

89106

Nevada Cancer Research Foundation CCOP, Las Vegas

90027

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90033

Los Angeles County-USC Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

90034

Kaiser Permanente-Cadillac, Los Angeles

90048

Cedars Sinai Medical Center, Los Angeles

90706

Kaiser Permanente-Bellflower, Bellflower

90710

Kaiser Permanente - Harbor City, Harbor City

91010

City of Hope Comprehensive Cancer Center, Duarte

91367

Kaiser Permanente, Woodland Hills

91402

Kaiser Permanente - Panorama City, Panorama City

91706

Kaiser Permanente-Baldwin Park, Baldwin Park

92069

Kaiser Permanente-San Marcos, San Marcos

92108

Kaiser Permanente-San Diego Mission, San Diego

92120

Kaiser Permanente-San Diego Zion, San Diego

92335

Kaiser Permanente Hospital, Fontana

92505

Kaiser Permanente-Riverside, Riverside

92618

Kaiser Permanente-Irvine, Irvine

92807

Kaiser Permanente-Anaheim, Anaheim

94010

Mills-Peninsula Medical Center, Burlingame

94115

California Pacific Medical Center-Pacific Campus, San Francisco

94304

Stanford Cancer Institute, Palo Alto

94589

Sutter Solano Medical Center/Cancer Center, Vallejo

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

94945

Sutter Cancer Research Consortium, Novato

95403

Sutter Pacific Medical Foundation, Santa Rosa

95817

University of California Davis Comprehensive Cancer Center, Sacramento

95901

Fremont - Rideout Cancer Center, Marysville

96161

Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee

98026

Swedish Medical Center-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98104

Harborview Medical Center, Seattle

Minor and James Medical PLLC, Seattle

98109

Fred Hutchinson Cancer Research Center, Seattle

98112

Group Health Cooperative-Seattle, Seattle

98166

Highline Medical Center-Main Campus, Burien

98195

University of Washington Medical Center, Seattle

98221

Cancer Care Center at Island Hospital, Anacortes

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98274

Skagit Valley Hospital, Mount Vernon

98284

United General Hospital, Sedro-Woolley

98310

Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton

98370

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo

98801

Wenatchee Valley Hospital and Clinics, Wenatchee

99202

Cancer Care Northwest - Spokane South, Spokane

99218

Evergreen Hematology and Oncology PS, Spokane

99336

Kadlec Clinic Hematology and Oncology, Kennewick

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

48106-0995

Saint Joseph Mercy Hospital, Ann Arbor

07018-1095

Veterans Adminstration New Jersey Health Care System, East Orange

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

98122-4307

Swedish Medical Center-First Hill, Seattle

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT01688973 - Tivantinib With or Without Erlotinib Hydrochloride in Treating Patients With Metastatic or Locally Advanced Kidney Cancer That Cannot Be Removed by Surgery | Biotech Hunter | Biotech Hunter