Phase II Combination of Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma

PHASE2CompletedINTERVENTIONAL
Enrollment

29

Participants

Timeline

Start Date

October 5, 2012

Primary Completion Date

April 26, 2016

Study Completion Date

January 9, 2020

Conditions
Hepatocellular Carcinoma
Interventions
DRUG

Temsirolimus

10 mg weekly will be administered intravenously over 30 to 60 minutes using an infusion pump starting on Cycle 1, Day 1 of study enrollment.

DRUG

Sorafenib:

200 mg tablet twice daily starting on Cycle 1, Day 1 of study enrollment after completion of temsirolimus infusion.

Trial Locations (2)

60611

Robert H Lurie Comprehensive Cancer Center, Chicago

94143

University of California, San Francisco, San Francisco

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Robert H. Lurie Cancer Center

OTHER

collaborator

Pfizer

INDUSTRY

lead

University of California, San Francisco

OTHER