A Study of Venetoclax in Combination With Obinutuzumab in Participants With Chronic Lymphocytic Leukemia

PHASE1CompletedINTERVENTIONAL
Enrollment

82

Participants

Timeline

Start Date

November 29, 2012

Primary Completion Date

May 21, 2018

Study Completion Date

August 23, 2019

Conditions
Lymphocytic Leukemia, Chronic
Interventions
DRUG

Obinutuzumab

Participants will receive IV infusion of obinutuzumab 100 milligrams (mg) on Day 1 of Cycle 1, 900 mg on Day 2 of Cycle 1, and 1000 mg on Days 8 and 15 of Cycle 1 and on Day 1 of Cycles 2-6.

DRUG

Venetoclax

Participants will receive multiple doses of venetoclax orally once daily.

Trial Locations (10)

10021

Weill Cornell Medical College-New York Presbyterian Hospital, New York

37203

SCRI-Tennessee Oncology, Nashville

43210

Ohio State University Comprehensive Cancer Center, Columbus

77030

The Methodist Hospital Research Institute; Academic Office of Clinical Trials, Houston

80218

Colorado Blood Cancer Institute (CBCI) at Presbyterian/ St. Luke's Medical Center, Denver

92093

UCSD Moores Cancer Center, La Jolla

97477

Oncology Associates of Oregon, Springfield

LS9 7TF

St James University Hospital, Leeds

LE1 5WW

Leicester Royal Infirmary NHS Trust, Leicester

E1 2AD

Barts and The London School of Medicine and Dentistry; Queen Mary, University of London, London

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

AbbVie (prior sponsor, Abbott)

INDUSTRY

lead

Genentech, Inc.

INDUSTRY