Sofosbuvir and Ribavirin in Treatment-Naive and Treatment-Experienced Subjects With Chronic Genotype 2 or 3 HCV Infection

PHASE3CompletedINTERVENTIONAL
Enrollment

421

Participants

Timeline

Start Date

September 30, 2012

Primary Completion Date

October 31, 2013

Study Completion Date

January 31, 2014

Conditions
Hepatitis C
Interventions
DRUG

SOF

Sofosbuvir (SOF) 400 mg tablet administered orally once daily

DRUG

RBV

Ribavirin (RBV) 200 mg tablets administered orally in a divided daily dose according to package insert weight-based dosing recommendations (\< 75 kg = 1000 mg and ≥ 75 kg = 1200 mg)

DRUG

Placebo to match SOF

Placebo to match SOF administered orally once daily

DRUG

Placebo to match RBV

Placebo to match RBV administered orally in a divided daily dose

Trial Locations (77)

133

Fondazione PTV - Policlinico Tor Vergata, Roma

149

"INMI Lazzaro Spallanzani I.R.C.C.S.", Roma

1090

Medizinische Universitat Wien, Vienna

1160

Wilhelminenspital, Vienna

4103

Universitaetsklinikum Leipzig, Leipzig

6202

Hopital de l Archet 2, Nice

10126

Azienda Ospedaliera Universitaria San Giovanni Battista di Torino, Torino

10617

West Tallinn Central Hospital, Tallinn

10969

Leber- and Studienzentrum am Checkpoint, Berlin

13008

Hopital Saint Joseph, Marseille

14186

Karolinska Instituet, Stockholm

16128

Ente Ospedaliero Ospedali Galliera, Genova

20099

Asklepios Klinik Sankt Georg H, Hamburg

20122

Fondazione IRCCS CA Granada - Ospedale Maggiore Policlinico, Milan

20162

Azienda Ospedaliera Ospedale Niguarda Cà Granda, Milan

20246

Universitatsklinikum, Hamburg

20502

Skanes Universitetssjukhus, Malmo

22185

Skånes Universitetssjukhus, Lund, Lund

24146

Leberstudienzentrum Kiel, Kiel

28029

Hospital Carlos III, Madrid

28046

Hospital Universitario La Paz, Madrid

28222

Hospital Puerta de Hierro Maja, Majadahonda

29071

Complejo Hospitalario de Especialidades Virgen de la Victoria, Málaga

30625

Medizinische Hochschule Hannov, Hanover

33604

Groupe Hospitalier Sud - Hôpital Haut-Lévêque - USN, Pessac

34295

Hopital Saint Eloi, Montpellier

35033

CHU Pontchaillou - Hématologie Clinique, Rennes

35100

University of Padova, Padua

38043

Département Hépatogastroentérologie - CHU de Grenoble, Grenoble

39008

Hospital Universitario Marques, Santander

40138

Azienda Ospedaliera di Bologna - Policlinico S. Orsola Malpighi, Bologna

40225

Heinrich Heine Unversitat, Düsseldorf

41014

Valme Hospital, Seville

41685

Sahlgrenska University Hospital, Gothenburg

43100

Azienda Ospedaliero Universitaria di Parma, Parma

44623

Gastroenterologische Gemeinsch, Herne

46014

Hospital General Universitario de Valencia, Valencia

50011

Ospedale S. Annunziata, Florence

51014

Tartu University Hospital, Tartu

53125

Universitaetsklinikum Bonn, Bonn

54511

CHU de Nancy, Hôpital de Brabois, Vandœuvre-lès-Nancy

59037

CHRU de Lille, Hopital Claude Huriez, CHRU Lille

60590

JWG-Universität Frankfurt, Frankfurt am Main

63003

CHU Estaing, Clermont-Ferrand

67091

Centre Hospitalier Universitaire de Strasbourg, Strasbourg

69120

Medizinische Klinik IV, Dep. o, Heidelberg

71013

Ospedale Casa Sollievo, San Giovanni Rotondo

75012

Hopital Saint Antoine, Paris

75013

Hopital Pitie Salpetriere, Paris

75679

Hopitaux Universitaires, Paris

79098

Praxiszentrum, Freiburg im Breisgau

81377

Klinikum der Universität Münch, München

90127

University of Palermo, Palermo

92110

Hopital Beaujon, Clichy

94000

Hopital Henri Mondor, Créteil

A-8036

Medizinische Universitat Graz, Graz

D-48143

Centrum fuer interdisziplinaere Medizin Muenster GmbH, Münster

1105 AZ

Academisch Medisch Centrum, Amsterdam

2300 RC

Leids Universitair Medisch Centrum, Leiden

6500 HB

UMC St. Radboud - Gastroenterology, Nijmegen

3015 CE

Erasmus MC, Rotterdam

15-540

Wojewodzki Szpital Specjalistyczny im Dluskeigo, Bialystok

91-347

Wojewodzki Specjalistyczny Szpital im. W. Bieganskiego, Lodz

01-201

SP ZOZ Wojewodzki Szpital Zakazny w Warszawie, Warsaw

50-349

NZOZ Centrum Badan Klinicznych, Wroclaw

08035

Hospital Universitari Vall d'H, Barcelona

08036

Hospital Casa de la Maternidad, Barcelona

B15 2TH

University of Birmingham, Edgbaston

SO41 3QP

Southampton University Hospital NHS Trust, Southhampton

SE5 9RS

King's College Hospital, Denmark Hill

W2 1NY

The Liver Unit, Paddington

M8 5RB

North Manchester General Hospital, Crumpsall

BS2 8HW

Bristol Royal Infirmary, Bristol

E1 2AT

Queen Marys University of London, London

NW3 2PF

Royal Free Hospital and University College London Hospital, London

SW109NH

Chelsea & Westminster Hospital, London

NG7 2UH

Nottingham University Hospitals-NHS, Nottingham

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY

NCT01682720 - Sofosbuvir and Ribavirin in Treatment-Naive and Treatment-Experienced Subjects With Chronic Genotype 2 or 3 HCV Infection | Biotech Hunter | Biotech Hunter