NCT01682408 - Assess Pharmacokinetics of Fostamatinib in Fed and Fasted State in Combination With Ranitidine to Assess Bioavailability | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

September 30, 2012

Primary Completion Date

December 31, 2012

Study Completion Date

December 31, 2012

Conditions

Pharmacokinetics

Interventions

DRUG

Fostamatinib - 1 x 150mg mannitol-based 38% drug-loaded tablet(orange reference)

1 x 150mg mannitol-based 38% drug-loaded tablet(orange reference)

DRUG

Fostamatinib - 3 x 50mg microcrystalline cellulose-based 13% drug loaded tablets,(blue) fed

3 x 50mg microcrystalline cellulose-based 13% drug loaded tablets,(blue) fed

DRUG

Fostamatinib - 1 x 150mg mannitol based 38% drug-loaded tablet (batch variant A)

1 x 150mg mannitol based 38% drug-loaded tablet (batch variant A)

DRUG

Fostamatinib - 1 x 150mg mannitol based 38% drug loaded tablet (batch variant B)

1 x 150mg mannitol based 38% drug loaded tablet(batch variant B)

DRUG

Ranitidine

150 mg ranitidine

Trial Locations (1)

Overland Park