13
Participants
Start Date
August 31, 2012
Primary Completion Date
June 30, 2016
Study Completion Date
August 31, 2016
[11C] desmethyl-loperamide
IV administration of 10-14 mCi of \[11C\] desmethyl-loperamide with PET/CT imaging
Control - no pretreatment
Session 1: IV administration of 10-14 mCi \[11C\] desmethyl-loperamide (dLop) with PET/CT imaging and brain MRI
Oral ritonavir
Session 2: Pretreatment with oral ritonavir for 3 days followed by IV administration of 10-14 mCi \[11C\]dLop with PET/CT imaging and brain MRI
Oral efavirenz
Session 3: Pretreatment with oral efavirenz for 14 days followed by IV administration of 10-14 mCi \[11C\]dLop with PET/CT imaging and brain MRI
Washington University School of Medicine, St Louis
Washington University School of Medicine
OTHER