564
Participants
Start Date
November 30, 2012
Primary Completion Date
December 31, 2015
Study Completion Date
December 31, 2015
5-Fluoruracil
Participants will receive 5-fluorouracil 400 milligrams per square meter (mg/m\^2) IV bolus and then 2400 mg/m\^2 as a continuous IV infusion over 46-48 hours on Day 1 of every cycle until disease progression or at the maximum of 12 cycles, whichever occurs first.
Folinic acid
Participants will receive folinic acid 400 mg/m\^2 IV infusion over 2 hours on Day 1 of every cycle until disease progression or at the maximum of 12 cycles, whichever occurs first.
Onartuzumab
Participants will receive onartuzumab 10 mg/kg IV infusion on Day 1 of every cycle (each cycle = 14 days) until disease progression, unacceptable toxicity, or participant or physician decision to discontinue treatment.
Oxaliplatin
Participants will receive oxaliplatin 85 mg/m\^2 IV infusion over 2 hours on Day 1 of every cycle until disease progression or at the maximum of 12 cycles, whichever occurs first.
Placebo
Participants will receive onartuzumab matching placebo on Day 1 of every cycle (each cycle = 14 days) until disease progression, unacceptable toxicity, or participant or physician decision to discontinue treatment.
Taipei
Taipei
Taichung
Taichung
Changhua
Hong Kong
Sydney
Port Macquarie
Leuven
Box Hill
Herston
Lucerne
Nedlands
Bruges
Zurich
Sint-Niklaas
New York
Turin
Bangkok
Bangkok
Bangkok
Albany
Marseille
Lopburi
Milan
Milan
Aguascalientes
Hamburg
Edirne
Besançon
Erzurum
Durham
Madrid
Madrid
Brest
Toulouse
Udine
St. Petersburg
Fort Myers
Marburg
Nashville
Santander
Malatya
Saint-Herblain
Bochum
Essen
Cincinnati
Angers
Zaragoza
Florence
Samsun
Chiang Rai
Prato
Kuala Lumpur
Chicago
Monterrey
Oaxaca City
Mannheim
Ludwigsburg
Paris
Paris
Paris
Tyler
Austin
Denver
München
Avignon
Catanzaro
Sabah
Los Angeles
Hat Yai
Clichy
Vancouver
Ivanovo
Singapore
Tula
Ryazan
Samara
Omsk
Ramat Gan
Providence
Providence
East Bentleigh
Hamilton
Toronto
Toronto
Toronto
Toronto
Montreal
Brno
Olomouc
Leipzig
Guatemala City
Hong Kong
Kaohisung
Jerusalem
Tel Aviv
Rome
Panama City
Bydgoszcz
Gdansk
Krakow
Lublin
Rybnik
Warsaw
Seoul
Seoul
Seoul
Seoul
Seoul
Seoul
Seoul
Elche
Barcelona
Barcelona
Barcelona
Taipei
Antalya
Sıhhiye, Ankara
Bristol
Cardiff
London
Manchester
Southampton
Sutton
Collaborators (1)
Genentech, Inc.
INDUSTRY
Hoffmann-La Roche
INDUSTRY