Anesthesia-analgesia Methods and Postoperative Delirium

NACompletedINTERVENTIONAL
Enrollment

1,800

Participants

Timeline

Start Date

November 21, 2011

Primary Completion Date

May 25, 2015

Study Completion Date

June 24, 2015

Conditions
ElderlyEpidural AnesthesiaGeneral AnesthesiaMajor SurgeryPostoperative Delirium
Interventions
PROCEDURE

Combined Epi-GA/PCEA

An epidural catheter will be placed before the induction of general anesthesia. General anesthesia will be induced and maintained as in the control group, with the addition of epidural anesthesia which will be maintained with the use of 0.375%-0.5% ropivacaine during surgery. Patient-controlled epidural analgesia will be provided after surgery.

PROCEDURE

GA/PCIA

General anesthesia will be induced with midazolam, propofol, sufentanil and rocuronium. Anesthesia will be maintained with either intravenous (propofol), inhalational (sevoflurane with or without nitrous oxide), or combined intravenous-inhalational anesthetics. Additional opioids (remifentanil, sufentanil, fentanyl, or morphine) and muscle relaxant (rocuronium, atracurium, or cisatracurium) will be administered when deemed necessary by the attending anesthesiologists. Patient-controlled intravenous analgesia will be provided after surgery.

Trial Locations (1)

100034

Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing

All Listed Sponsors
collaborator

Peking University People's Hospital

OTHER

collaborator

Peking University Third Hospital

OTHER

collaborator

Beijing Hospital

OTHER_GOV

collaborator

Beijing Shijitan Hospital, Capital Medical University

OTHER

lead

Peking University First Hospital

OTHER

NCT01661907 - Anesthesia-analgesia Methods and Postoperative Delirium | Biotech Hunter | Biotech Hunter