700
Participants
Start Date
December 10, 2012
Primary Completion Date
March 11, 2023
Study Completion Date
November 4, 2024
Radical Hysterectomy + pelvic lymph node dissection
This procedure may be performed abdominally, laparoscopically, robotically or vaginally. The uterus, cervix, medial 1/3 of parametria, 2cm of the uterosacral ligaments and upper 1-2cm of the vagina are to be removed en bloc. The uterine artery is ligated laterally to the ureters and the ureters are unroofed to the ureterovesical junction.
Simple hysterectomy + pelvic lymph node dissection
This procedure may be performed abdominally, laparoscopically, robotically or vaginally. Extrafascial hysterectomy involves removal of the uterus with cervix without adjacent parametria. The uterine arteries are transected medial to the ureters at the level of the isthmus and the uterosacral ligaments are transected at the level of the cervix. Surgeons should pay special attention to make sure that the whole cervix is removed. As such, a maximum of 0.5 cm of vaginal cuff can be removed to ensure the complete removal of the cervix.
Medical University of Vienna, Vienna
UZ Leuven, Leuven
CHR de la Citadelle liege, Liège
CHU Sart Tilman Liege, Liège
Landes- Frauen- und Kinderklinik Linz, Linz
LKH Salzburg, Salzburg
Medical University of Innsbruck, Innsbruck
Barmherzige Brueder Graz, Graz
Medical University of Graz, Graz
LKH Leoben, Leoben
DRK Kliniken Berlin Koepenick, Berlin
Institut Paoli Calmettes - Marseille, Marseille
DRK Klinikum Berlin Westend, Berlin
Martin-Luther-Krankenhaus Berlin, Berlin
Universitaetsfrauenklinik Greifswald, Greifswald
Universitaetsklinikum Hamburg - Eppendorf, Hamburg
Agaplesion Diakonieklinikum Hamburg, Hamburg
Centre Georges Francois Leclerc - Dijon, Dijon
CHU de Dijon, Dijon
Universitaetsfrauenklinik Luebeck, Lübeck
GYNAEKOLOGICUM Bremen, Bremen
CHRU de Brest, Brest
CHU de Nimes, Nîmes
Medizinische Hochschule Hannover, Hanover
Institut Claudius Regaud - Toulouse, Toulouse
Institut Bergonie Bordeaux, Bordeaux
CHU de Bordeaux, Talence
Institut Regional du Cancer de Montpellier, Montpellier
CHU de Rennes, Rennes
Clinique Mutualiste de la Sagesse - Rennes, Rennes
CHRU de Tours, Tours
Universitaetsfrauenklinik Duesseldorf, Düsseldorf
Kaiserswerther Diakonie - Florence-Nightingale-Krankenhaus, Düsseldorf
ICO - Rene Gauducheau, Saint-Herblain
Kliniken Essen Mitte, Essen
CHU de Reims, Reims
Universitaetsfrauenklinik Mainz, Mainz
Marien-Hospital Witten, Witten
Centre Oscar Lambret - Lille, Lille
CHRU de Lille, Lille
Hochtaunus-Kliniken gGmbH, Bad Homburg
CHU de Clermont-Ferrand, Clermont-Ferrand
Centre Jean Perrin - Clermont-Ferrand, Clermont-Ferrand
Universitaetsklinikum des Saarlandes, Homburg-Saar
CHU de Strasbourg, Strasbourg
Hospices Civils de Lyon, Lyon
Centre Leon Berard - Lyon, Lyon
Universitaetsfrauenklinik Tuebingen, Tübingen
CHU de Chambery, Chambéry
Hopital Europeen Georges Pompidou - Paris, Paris
Clinique Mathilde - Rouen, Rouen
Universitaetsfrauenklinik Freiburg, Freiburg im Breisgau
CHU Amiens, Amiens
Klinikum der Universitaet Muenchen - LMU Campus Grosshadern, München
CHU Limoges, Limoges
Universitaetsfrauenklinik Ulm, Ulm
Shanghai Cancer Center, Shanghai
Tom Baker Cancer Centre, Calgary
Cross Cancer Institute, Edmonton
Clinical Research Unit at Vancouver Coastal, Vancouver
CancerCare Manitoba, Winnipeg
QEII Health Sciences Centre, Halifax
Royal Victoria Regional Health Centre, Barrie
London Regional Cancer Program, London
Trillium Health Partners - Credit Valley Hospital, Mississauga
Ottawa Hospital Research Institute, Ottawa
University Health Network, Toronto
Greenfield Park
CIUSSS de l'Est-de-I'lle-de-Montreal, Montreal
CHUM-Centre Hospitalier de l'Universite de Montreal, Montreal
The Jewish General Hospital, Montreal
Québec
CIUSSS de l'Estrie - Centre hospitalier, Sherbrooke
Institut Arnault Tzank - Mougins, Mougins
CHU de Nice, Nice
Universitaetsfrauenklinik Jena, Jena
St James Hospital, Dublin
LUMC, Leiden
Erasmus MC, Rotterdam
Oslo University Hospital, Oslo
Hertzen Moscow Scientific Research, Moscow
Royal Cornwall Hospital, Truro
Southend University Hospital, Westcliff-on-Sea
East Kent Hospitals University NHS Foundation Trust, Canterbury
Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield
South Tees Hospitals NHS Foundation Trust, Middlesbrough
Queen Alexandra Hospital, Portsmouth
Gynecologic Cancer Intergroup (GCIG)
OTHER
Canadian Institutes of Health Research (CIHR)
OTHER_GOV
Korean Gynecologic Oncology Group
OTHER
Dutch Gynaecological Oncology Group
OTHER
Cancer Trials Ireland
NETWORK
Arbeitsgemeinschaft Gynaekologische Onkologie Austria
OTHER
Belgian Gynaecological Oncology Group
OTHER
ARCAGY/ GINECO GROUP
OTHER
Institute of Cancer Research, United Kingdom
OTHER
Shanghai Cancer Centre
OTHER
P. Herzen Moscow Oncology Research Institute
OTHER_GOV
Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom Germany
OTHER
Institut Universitaire du Cancer de Toulouse
OTHER
Canadian Cancer Trials Group
NETWORK