A Study of LY3023414 in Participants With Advanced Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

156

Participants

Timeline

Start Date

July 31, 2012

Primary Completion Date

April 4, 2019

Study Completion Date

February 2, 2022

Conditions
Advanced CancerMetastatic CancerNon-Hodgkin's LymphomaMetastatic Breast CancerMalignant MesotheliomaNon-small Cell Lung Cancer
Interventions
DRUG

LY3023414

Administered orally. Dose of 20 to 600 mg, as determined in Part A.

DRUG

Midazolam

0.2 mg administered orally once before LY3023414 on Day 1 and once after LY3023414 on Day 15.

DRUG

Fulvestrant

500 mg administered IM on Day 1 and Day 15 in cycle 1 and Day 1 every 28 days for additional cycles.

DRUG

Pemetrexed

500 mg/m2 administered IV once on Day 1 every 21 days

DRUG

Cisplatin

75 mg/m2 administered IV once on Day 1 every 21 days

DRUG

Abemaciclib

Administered orally

DRUG

Letrozole

Administered orally

Trial Locations (8)

10043

Azienda Ospedaliero - Universitaria S. Luigi Gonzaga, Orbassano

10065

Memorial Sloan Kettering Cancer Center, New York

19104

Penn Presbyterian Medical Center, Philadelphia

37203

Sarah Cannon Cancer Center, Nashville

Tennessee Oncology PLLC, Nashville

73104

Peggy and Charles Stephenson Oklahoma Cancer Center, Oklahoma City

90095

UCLA Medical Center, Los Angeles

00927

Fundacion de Investigacion de Diego, San Juan

All Listed Sponsors
lead

Eli Lilly and Company

INDUSTRY

NCT01655225 - A Study of LY3023414 in Participants With Advanced Cancer | Biotech Hunter | Biotech Hunter