Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

116

Participants

Timeline

Start Date

November 30, 2012

Primary Completion Date

May 11, 2016

Study Completion Date

April 15, 2017

Conditions
Adult Anaplastic AstrocytomaAdult Anaplastic OligodendrogliomaAdult Giant Cell GlioblastomaAdult GlioblastomaAdult GliosarcomaAdult Mixed GliomaRecurrent Adult Brain Neoplasm
Interventions
BIOLOGICAL

Anti-Endoglin Chimeric Monoclonal Antibody TRC105

Given IV

BIOLOGICAL

Bevacizumab

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

OTHER

Pharmacological Study

Correlative studies

OTHER

Quality-of-Life Assessment

Ancillary studies

Trial Locations (308)

10029

Mount Sinai Hospital, New York

10065

Memorial Sloan-Kettering Cancer Center, New York

13021

Hematology Oncology Associates of Central New York-Auburn, Auburn

13057

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse

13210

State University of New York Upstate Medical University, Syracuse

13215

Hematology Oncology Associates of Central New York-Onondaga Hill, Syracuse

17109

PinnacleHealth Cancer Center-Community Campus, Harrisburg

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

19611

Reading Hospital, West Reading

19713

Christiana Gynecologic Oncology LLC, Newark

Delaware Clinical and Laboratory Physicians PA, Newark

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

Regional Hematology and Oncology PA, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19801

Christiana Care Health System-Wilmington Hospital, Wilmington

19958

Beebe Medical Center, Lewes

19971

Beebe Health Campus, Rehoboth Beach

19973

Nanticoke Memorial Hospital, Seaford

22401

Fredericksburg Oncology Inc, Fredericksburg

22908

University of Virginia Cancer Center, Charlottesville

27157

Wake Forest University Health Sciences, Winston-Salem

27534

Wayne Memorial Hospital, Goldsboro

28501

Kinston Medical Specialists PA, Kinston

29307

Greenville Health System Cancer Institute-Spartanburg, Spartanburg

29605

Greenville Health System Cancer Institute-Andrews, Greenville

Greenville Health System Cancer Institute-Butternut, Greenville

Greenville Health System Cancer Institute-Faris, Greenville

Greenville Memorial Hospital, Greenville

29615

Greenville Health System Cancer Institute-Eastside, Greenville

29640

Greenville Health System Cancer Institute-Easley, Easley

29650

Greenville Health System Cancer Institute-Greer, Greer

29672

Greenville Health System Cancer Institute-Seneca, Seneca

32803

Florida Hospital Orlando, Orlando

33140

Mount Sinai Medical Center, Miami Beach

40503

Baptist Health Lexington, Lexington

40701

Baptist Health Corbin, Corbin

41017

Oncology Hematology Care Inc-Crestview, Crestview Hills

42003

Baptist Health Paducah, Paducah

42431

Baptist Health Madisonville/Merle Mahr Cancer Center, Madisonville

42701

Hardin Memorial Hospital, Elizabethtown

43015

Delaware Health Center-Grady Cancer Center, Delaware

Delaware Radiation Oncology, Delaware

Grady Memorial Hospital, Delaware

43050

Knox Community Hospital, Mount Vernon

43055

Licking Memorial Hospital, Newark

Newark Radiation Oncology, Newark

43081

Saint Ann's Hospital, Westerville

43130

Fairfield Medical Center, Lancaster

43214

Columbus Oncology and Hematology Associates Inc, Columbus

Riverside Methodist Hospital, Columbus

43215

Columbus NCI Community Oncology Research Program, Columbus

Grant Medical Center, Columbus

43219

The Mark H Zangmeister Center, Columbus

43222

Mount Carmel Health Center West, Columbus

43228

Doctors Hospital, Columbus

43302

OneHealth Marion General Hospital, Marion

43402

Toledo Clinic Cancer Centers-Bowling Green, Bowling Green

43537

Toledo Clinic Cancer Centers-Maumee, Maumee

Toledo Radiation Oncology at Northwest Ohio Onocolgy Center, Maumee

43560

Flower Hospital, Sylvania

43567

Fulton County Health Center, Wauseon

43608

Saint Vincent Mercy Medical Center, Toledo

43614

University of Toledo, Toledo

43616

Saint Charles Hospital, Oregon

Toledo Clinic Cancer Centers-Oregon, Oregon

43617

Toledo Community Hospital Oncology Program CCOP, Toledo

43623

Mercy Saint Anne Hospital, Toledo

Toledo Clinic Cancer Centers-Toledo, Toledo

43701

Genesis Healthcare System Cancer Care Center, Zanesville

44883

Mercy Hospital of Tiffin, Tiffin

45014

Oncology Hematology Care Inc-Healthplex, Fairfield

45202

Oncology Hematology Care Inc-Eden Park, Cincinnati

45211

Oncology Hematology Care Inc-Mercy West, Cincinnati

45230

Oncology Hematology Care Inc - Anderson, Cincinnati

45236

Oncology Hematology Care Inc-Kenwood, Cincinnati

45242

Oncology Hematology Care Inc-Blue Ash, Cincinnati

45331

Wayne Hospital, Greenville

45373

Upper Valley Medical Center, Troy

45406

Good Samaritan Hospital - Dayton, Dayton

45409

Miami Valley Hospital, Dayton

45415

Samaritan North Health Center, Dayton

45429

Kettering Medical Center, Kettering

45505

Springfield Regional Medical Center, Springfield

45601

Adena Regional Medical Center, Chillicothe

45662

Southern Ohio Medical Center, Portsmouth

45714

Strecker Cancer Center-Belpre, Belpre

45750

Marietta Memorial Hospital, Marietta

45804

Lima Memorial Hospital, Lima

45840

Blanchard Valley Hospital, Findlay

46202

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

46307

Michiana Hematology Oncology PC-Crown Point, Crown Point

46350

IU Health La Porte Hospital, La Porte

46391

Michiana Hematology Oncology PC-Westville, Westville

46514

Michiana Hematology Oncology PC-Elkhart, Elkhart

46515

Elkhart General Hospital, Elkhart

46544

Memorial Regional Cancer Center Day Road, Mishawaka

46545

Michiana Hematology Oncology PC-Mishawaka, Mishawaka

Saint Joseph Regional Medical Center-Mishawaka, Mishawaka

46563

Michiana Hematology Oncology PC-Plymouth, Plymouth

46601

Memorial Hospital of South Bend, South Bend

Michiana Hematology Oncology PC-South Bend, South Bend

46617

South Bend Clinic, South Bend

46628

Northern Indiana Cancer Research Consortium, South Bend

46904

Community Howard Regional Health, Kokomo

47374

Reid Health, Richmond

48060

Lake Huron Medical Center, Port Huron

48093

Saint John Macomb-Oakland Hospital, Warren

48124

Beaumont Hospital-Dearborn, Dearborn

48154

Saint Mary Mercy Hospital, Livonia

48162

Mercy Memorial Hospital, Monroe

Toledo Clinic Cancer Centers-Monroe, Monroe

48197

Ann Arbor Hematology -Oncology Associates, Ypsilanti

48236

Saint John Hospital and Medical Center, Detroit

48341

Saint Joseph Mercy Oakland, Pontiac

48502

Hurley Medical Center, Flint

48503

Genesys Hurley Cancer Institute, Flint

48601

Saint Mary's of Michigan, Saginaw

48912

Sparrow Hospital, Lansing

49001

Borgess Medical Center, Kalamazoo

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49085

Lakeland Hospital, Saint Joseph

Marie Yeager Cancer Center, Saint Joseph

49120

Lakeland Community Hospital, Niles

49201

Allegiance Health, Jackson

49221

Bixby Medical Center, Adrian

Hickman Cancer Center, Adrian

49444

Mercy Health Mercy Campus, Muskegon

49503

Mercy Health Saint Mary's, Grand Rapids

Spectrum Health at Butterworth Campus, Grand Rapids

49677

Spectrum Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

50010

Mary Greeley Medical Center, Ames

McFarland Clinic PC-William R Bliss Cancer Center, Ames

50036

McFarland Clinic PC-Boone, Boone

50129

McFarland Clinic PC-Jefferson, Jefferson

50158

McFarland Clinic PC-Marshalltown, Marshalltown

50501

McFarland Clinic PC-Trinity Cancer Center, Fort Dodge

51101

Siouxland Regional Cancer Center, Sioux City

51104

Mercy Medical Center-Sioux City, Sioux City

Saint Luke's Regional Medical Center, Sioux City

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

52403

Mercy Hospital, Cedar Rapids

Oncology Associates at Mercy Medical Center, Cedar Rapids

52722

Constantinou, Costas L MD (UIA Investigator), Bettendorf

53051

Community Memorial Hospital, Menomonee Falls

53066

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53149

ProHealth D N Greenwald Center, Mukwonago

53188

ProHealth Waukesha Memorial Hospital, Waukesha

53226

Froedtert and the Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Hospital and Clinics, Madison

54017

Cancer Center of Western Wisconsin, New Richmond

54601

Gundersen Lutheran Medical Center, La Crosse

55082

Lakeview Hospital, Stillwater

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55350

Hutchinson Area Health Care, Hutchinson

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Metro Minnesota Community Oncology Research Consortium, Saint Louis Park

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview-Southdale Hospital, Edina

55454

Health Partners Inc, Minneapolis

55805

Essentia Health Cancer Center, Duluth

Essentia Health Saint Mary's Medical Center, Duluth

Miller-Dwan Hospital, Duluth

Saint Luke's Hospital of Duluth, Duluth

55905

Mayo Clinic, Rochester

56073

New Ulm Medical Center, New Ulm

56201

Rice Memorial Hospital, Willmar

56303

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

Saint Cloud Hospital, Saint Cloud

57701

Rapid City Regional Hospital, Rapid City

58201

Altru Cancer Center, Grand Forks

59101

Billings Clinic Cancer Center, Billings

Montana Cancer Consortium NCORP, Billings

Saint Vincent Healthcare, Billings

59405

Benefis Healthcare- Sletten Cancer Institute, Great Falls

59601

Saint Peter's Community Hospital, Helena

59701

Saint James Community Hospital and Cancer Treatment Center, Butte

59715

Bozeman Deaconess Hospital, Bozeman

59802

Saint Patrick Hospital - Community Hospital, Missoula

59804

Community Medical Hospital, Missoula

59901

Kalispell Regional Medical Center, Kalispell

60026

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

Hematology Oncology Associates of Illinois-Highland Park, Highland Park

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60048

NorthShore Hematology Oncology-Libertyville, Libertyville

60076

Hematology Oncology Associates of Illinois - Skokie, Skokie

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60714

Illinois Cancer Specialists-Niles, Niles

60901

Presence Saint Mary's Hospital, Kankakee

61265

Garneau, Stewart C MD (UIA Investigator), Moline

Spector, David MD (UIA Investigator), Moline

Trinity Medical Center, Moline

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

Radiation Oncology of Northern Illinois, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center, Pekin

61603

Methodist Medical Center of Illinois, Peoria

61615

Illinois CancerCare-Peoria, Peoria

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61701

Saint Joseph Medical Center, Bloomington

61704

Illinois CancerCare-Bloomington, Bloomington

62226

Cancer Care Specialists of Illinois-Swansea, Swansea

62321

Illinois CancerCare-Carthage, Carthage

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Center of Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Central Illinois Hematology Oncology Center, Springfield

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Memorial Medical Center, Springfield

62801

Centralia Oncology Clinic, Centralia

62902

Memorial Hospital of Carbondale, Carbondale

63080

Missouri Baptist Sullivan Hospital, Sullivan

63110

Washington University School of Medicine, St Louis

63127

Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills

63131

Missouri Baptist Medical Center, St Louis

63628

Parkland Health Center-Bonne Terre, Bonne Terre

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

Southeast Cancer Center, Cape Girardeau

65109

Capital Region Medical Center-Goldschmidt Cancer Center, Jefferson City

66044

Lawrence Memorial Hospital, Lawrence

66502

Cancer Center of Kansas-Manhattan, Manhattan

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas - Chanute, Chanute

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Associates In Womens Health, Wichita

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Cancer Center of Kansas - Wichita, Wichita

Via Christi Regional Medical Center, Wichita

Wichita NCI Community Oncology Research Program, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

67460

Cancer Center of Kansas - McPherson, McPherson

67801

Cancer Center of Kansas - Dodge City, Dodge City

67905

Cancer Center of Kansas-Liberal, Liberal

68198

University of Nebraska Medical Center, Omaha

72205

University of Arkansas for Medical Sciences, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

74146

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

78701

University Medical Center Brackenridge, Austin

82414

Big Horn Basin Cancer Center, Cody

Billings Clinic-Cody, Cody

82609

Rocky Mountain Oncology, Casper

82801

Welch Cancer Center, Sheridan

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83814

Kootenai Medical Center, Coeur d'Alene

83854

Kootenai Cancer Center, Post Falls

83864

Kootenai Cancer Clinic, Sandpoint

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

92123

Sharp Memorial Hospital, San Diego

92835

Saint Jude Medical Center, Fullerton

92868

Saint Joseph Hospital - Orange, Orange

94115

UCSF Medical Center-Mount Zion, San Francisco

94143

UCSF Medical Center-Parnassus, San Francisco

06830

Greenwich Hospital, Greenwich

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06904

Stamford Hospital/Bennett Cancer Center, Stamford

32224-9980

Mayo Clinic in Florida, Jacksonville

46514-2098

Elkhart Clinic, Elkhart

04401

Eastern Maine Medical Center, Bangor

04412

Lafayette Family Cancer Center-EMMC, Brewer

04074

Maine Center for Cancer Medicine-Scarborough, Scarborough

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Dana-Farber Cancer Institute, Boston

02129

Massachusetts General Hospital, Charlestown

48106-0995

Saint Joseph Mercy Hospital, Ann Arbor

03301

New Hampshire Oncology Hematology PA-Concord, Concord

03106

New Hampshire Oncology Hematology PA-Hooksett, Hooksett

03246

LRGHealthcare-Lakes Region General Hospital, Laconia

03756

Dartmouth Hitchcock Medical Center, Lebanon

08103

Cooper Hospital University Medical Center, Camden

08043

MD Anderson Cancer Center at Cooper-Voorhees, Voorhees Township

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT01648348 - Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme | Biotech Hunter | Biotech Hunter