NCT01641289View on ClinicalTrials.gov

Paracetamol Effect on Oxidative Stress and Renal Function in Severe Malaria

NACompletedINTERVENTIONAL
Enrollment

62

Participants

Timeline

Start Date

July 10, 2012

Primary Completion Date

September 13, 2014

Study Completion Date

September 21, 2014

Conditions
Malaria
Interventions
DRUG

Paracetamol

\>50kg: Paracetamol 1gm PO/NG q6hourly for 72hours and afebrile for 24h (maximum total dose 4g/24 hours) plus intravenous Artesunate \<50kg: Paracetamol 12.5-15mg/kg/dose q6hourly for 72hours and afebrile for 24h (maximum total dose 5 doses/24hours;75mg/kg) plus intravenous Artesunate

DRUG

No Paracetamol

"No paracetamol + Intravenous Artesunate~* If temperature \> 40°C, ibuprofen PO/PR will be administered in the absence of renal impairment and dehydration; 500mg paracetamol PO/PR will be administered in the presence of renal impairment or dehydration. Dengue testing will be done prior to the administration of ibuprofen."

Trial Locations (2)

Unknown

Chittagong Medical College Hospital, Chittagong

Ramu Upazilla Health Complex, Rāmu

All Listed Sponsors
lead

University of Oxford

OTHER

NCT01641289 - Paracetamol Effect on Oxidative Stress and Renal Function in Severe Malaria | Biotech Hunter | Biotech Hunter