A Phase 2a Study of Modified Vaccinia Virus to Treat Sorafenib-naïve Advanced Liver Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

16

Participants

Timeline

Start Date

June 30, 2012

Primary Completion Date

June 30, 2013

Study Completion Date

June 30, 2013

Conditions
Hepatocellular Carinoma
Interventions
BIOLOGICAL

JX-594 recombinant vaccina GM-CSF

Enrolled patients will receive 5 weekly IV infusions on Days 1, 8, 15, 22, and 29. After Day 43, if their disease has improved or remained stable and they have not started other cancer therapy, they may be able to continue to receive JX-594 via IV infusion every three weeks. This treatment extension may continue until radiologic progressive disease, initiation of other cancer therapy, or patient withdrawal.

Trial Locations (5)

78229

University of Texas Health Science Center at San Antonio, San Antonio

85259

Mayo Clinic, Scottsdale

Unknown

Pusan National University Hospital, Pusan

Pusan National University Yangsan Hospital, Yangsan

University Clinic of Navarra, Pamplona

Sponsors
All Listed Sponsors
lead

Jennerex Biotherapeutics

INDUSTRY

NCT01636284 - A Phase 2a Study of Modified Vaccinia Virus to Treat Sorafenib-naïve Advanced Liver Cancer | Biotech Hunter | Biotech Hunter