A Study of CSL362 in Patients With CD123+ Acute Myeloid Leukemia Currently in Remission

PHASE1CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

July 31, 2012

Primary Completion Date

August 31, 2015

Conditions
Leukemia, Myeloid, Acute
Interventions
BIOLOGICAL

CSL362

"CSL362 is humanized monoclonal antibody that targets the alpha chain of the interleukin 3 receptor (IL3Rα; also known as CD123) and is optimised for enhanced activation of antibody-dependent cell-mediated cytotoxicity (ADCC) via natural killer cells.~CSL362 is a sterile solution for injection and will be administered by intravenous infusion to subjects in sequential, escalating dose level cohorts, at doses up to 12.0 mg/kg. CSL362 will be administered every 14 days for a total of 6 infusions per subject. The 6 infusions for each individual subject will contain the same dose of CSL362."

Trial Locations (5)

3050

Royal Melbourne Hospital, Parkville

10065

Weill Cornell Medical College, New York

21287

Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore

60611

Robert H. Lurie Comprehensive Cancer Center of Northwestern University Medical School, Chicago

98109

Seattle Cancer Care Alliance, Seattle

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Parexel

INDUSTRY

lead

CSL Limited

INDUSTRY