10
Participants
Start Date
July 18, 2012
Primary Completion Date
January 9, 2013
Study Completion Date
January 23, 2013
Placebo
Two gross-matched glimepiride placebo tablets taken on Day -1 and Day 1 of the three treatment periods.
Glimepiride 2 mg
One placebo tablet and one 2-mg glimepiride tablet taken on Day -1 and Day 1 of the three treatment periods.
Glimepiride 4 mg
Two 2-mg glimepiride tablets taken on Day -1 and Day 1 of the three treatment periods.
Hypoglycemic Clamp
On Day 1 of the three treatment periods, 180 minutes after drug treatment, a fixed-rate insulin infusion is combined with a variable-rate dextrose infusion to maintain plasma glucose concentrations at close to 50 mg/dL for 30 minutes.
Merck Sharp & Dohme LLC
INDUSTRY