The Effect of Non-Steroidal Anti-Inflammatory Drug Naproxen on Pleural Effusion Formation After Lung Resection

PHASE2TerminatedINTERVENTIONAL
Enrollment

7

Participants

Timeline

Start Date

April 30, 2014

Primary Completion Date

January 31, 2018

Study Completion Date

January 31, 2018

Conditions
Pleural EffusionPleural Effusion Malignant
Interventions
DRUG

Naproxen

Intervention arm involves administering 500mg Naproxen BID to participants and 40mg of Pantoprazole in tandem. Pantoprazole will negate gastrointestinal consequences of Naproxen and reduce the likelihood of a complication occurring. Participants will take Naproxen at the above dosage from the time of surgery to four weeks following surgery. They will attend scheduled check-ups where their vitals will be recorded, as well as laboratory indicators of gastrointestinal complications (creatinine levels, etc) for their safety. This experiment is double-blinded so neither investigators nor participants will know which arm of the study they belong to.

DRUG

Placebo

Inert, inactive placebo pill similar in appearance to naproxen allocation. To be taken twice daily for 4 weeks total along with 40mg pantoprazole.

Trial Locations (1)

L8N 4A6

St. Joseph's Healthcare Hamilton, Hamilton

Sponsors
All Listed Sponsors
collaborator

McMaster Surgical Associates

OTHER

lead

McMaster University

OTHER

NCT01612975 - The Effect of Non-Steroidal Anti-Inflammatory Drug Naproxen on Pleural Effusion Formation After Lung Resection | Biotech Hunter | Biotech Hunter